{"id":"W4211265371","doi":"10.1002/alz.12607","title":"Protein phosphatase 2A and complement component 4 are linked to the protective effect of <i>APOE</i> ɛ2 for Alzheimer's disease","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institutes of Health; Northwestern University; York University; National Human Genome Research Institute; Duke University; Wellcome Trust; School of Medicine, Indiana University; Johns Hopkins University; National Institute of Mental Health; Boston University; Indiana University; Oregon Health and Science University; National Cancer Institute; Emory University; Rush University; U.S. Department of Veterans Affairs; New York University; Massachusetts General Hospital; National Institute on Aging; Columbia University; Alzheimer's Association; Mayo Clinic; Howard Hughes Medical Institute","keywords":"Apolipoprotein E; Protein phosphatase 2; Allele; Protein subunit; Biology; Complement system; Induced pluripotent stem cell; Tau protein; Alzheimer's disease; Single-nucleotide polymorphism; C4A; Molecular biology; Gene; Genetics; Disease; Genotype; Internal medicine; Medicine; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002246407,0.0004506512,0.0002375005,0.0006526741,0.0002056018,0.0003671344,0.000167251,0.0002701851,0.002052565],"category_scores_gemma":[0.0004630031,0.0001531144,0.0003727942,0.0004610676,0.0002251524,0.00008465203,0.0001532866,0.0002816117,0.0001472357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001208304,"about_ca_system_score_gemma":0.0001393156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001911969,"about_ca_topic_score_gemma":0.001146248,"domain_scores_codex":[0.9998547,0.00003838458,0.00001527343,0.00004545961,0.00002524263,0.00002087933],"domain_scores_gemma":[0.9996989,0.00005840875,0.0001498229,0.00002016682,0.00002533104,0.00004738735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004431327,0.0001600151,0.7935494,0.00009000979,0.0007332684,0.001169844,0.0001105087,0.0002602188,0.1905989,0.0002722394,0.0003592423,0.008264897],"study_design_scores_gemma":[0.0000308637,0.0002448698,0.9879794,0.000009818817,0.0003466766,0.001384001,0.00005402673,0.0006145775,0.008791967,0.00020885,0.0003270672,0.000007849093],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992492,0.0002432617,0.0002057809,0.00002833285,0.000004345058,0.000002365101,0.0001051944,0.000006988576,0.0001545483],"genre_scores_gemma":[0.9994144,0.00008860815,0.0001946059,0.00001416199,0.000006941128,0.000002243436,0.00008659171,0.000002754197,0.0001897114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002052565,"threshold_uncertainty_score":0.006866574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02346798908832679,"score_gpt":0.269071511893125,"score_spread":0.2456035228047982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}