{"id":"W4212763347","doi":"10.1128/spectrum.01203-21","title":"Hydroxyl Radical Overproduction in the Envelope: an Achilles’ Heel in Peptidoglycan Synthesis","year":2022,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Kempestiftelserna; Université de Montréal; Knut och Alice Wallenbergs Stiftelse; Government of Canada; Vetenskapsrådet; Natural Sciences and Engineering Research Council of Canada; Kempe Foundation","keywords":"Cell envelope; Peptidoglycan; Cell biology; Oxidative stress; Biology; Mutant; Biochemistry; Overproduction; Oxidative phosphorylation; DNA damage; Bacterial cell structure; Reactive oxygen species; Inner membrane; Chemistry; Escherichia coli; Cell wall; Mitochondrion; DNA; Bacteria; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002320084,0.0007124022,0.0009484193,0.0005371359,0.0007391133,0.002354901,0.0007468207,0.002713692,0.001764148],"category_scores_gemma":[0.00140939,0.0003554806,0.0003836861,0.0003723648,0.001512918,0.007379347,0.001351599,0.004509985,0.0008326485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007550386,"about_ca_system_score_gemma":0.001069574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004176939,"about_ca_topic_score_gemma":0.0004466354,"domain_scores_codex":[0.9993649,0.0001118232,0.00004584895,0.0001180781,0.0002193562,0.0001400319],"domain_scores_gemma":[0.9984549,0.0004476368,0.0002445105,0.0001305024,0.0003570203,0.0003653516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00120775,0.0001952829,0.007514186,0.004466331,0.000298339,0.004414309,0.0009380661,0.001080488,0.6683314,0.03710891,0.01239529,0.2620497],"study_design_scores_gemma":[0.0002345984,0.003982641,0.02502976,0.002948421,0.000374158,0.01303732,0.006443205,0.004220292,0.5423266,0.1450803,0.2558698,0.0004529362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3657217,0.4735602,0.03456646,0.1091951,0.009424471,0.00008008107,0.0004074885,0.0005979054,0.006446605],"genre_scores_gemma":[0.6979363,0.2555493,0.01578797,0.01302595,0.00491371,0.00008213462,0.0003571408,0.0001004061,0.012247],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002713692,"threshold_uncertainty_score":0.01226991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008445836193116464,"score_gpt":0.242297483580667,"score_spread":0.2338516473875505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}