{"id":"W4212763347","doi":"10.1128/spectrum.01203-21","title":"Hydroxyl Radical Overproduction in the Envelope: an Achilles’ Heel in Peptidoglycan Synthesis","year":2022,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Kempestiftelserna; Université de Montréal; Knut och Alice Wallenbergs Stiftelse; Government of Canada; Vetenskapsrådet; Natural Sciences and Engineering Research Council of Canada; Kempe Foundation","keywords":"Cell envelope; Peptidoglycan; Cell biology; Oxidative stress; Biology; Mutant; Biochemistry; Overproduction; Oxidative phosphorylation; DNA damage; Bacterial cell structure; Reactive oxygen species; Inner membrane; Chemistry; Escherichia coli; Cell wall; Mitochondrion; DNA; Bacteria; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008694012,0.0001659104,0.0002001904,0.0001335402,0.0002160544,0.00001564436,0.0005183428,0.00009475668,0.0001847259],"category_scores_gemma":[0.000136216,0.0001368683,0.00005976569,0.0002311301,0.0002528921,0.000005028327,0.000419644,0.0003773736,0.00001048381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001102316,"about_ca_system_score_gemma":0.00009384268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002554494,"about_ca_topic_score_gemma":0.001671798,"domain_scores_codex":[0.9978669,0.0007984926,0.0002378014,0.0005473094,0.00007374246,0.0004757468],"domain_scores_gemma":[0.9994178,0.00003318441,0.00005546199,0.0004529493,0.000008085028,0.00003246648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002501866,0.0002255264,0.01099784,0.000005185535,0.0000305455,0.00002890832,0.0003268627,0.00006773446,0.985398,0.00008375896,0.002056448,0.0005290167],"study_design_scores_gemma":[0.002293513,0.002137551,0.2341077,0.00001670784,0.00002592257,0.001247901,0.003525655,0.00004896528,0.3871391,0.0004017394,0.3681082,0.0009469801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930691,0.0004076256,0.000006365416,0.005590862,0.000165495,0.0002993767,0.00006776259,0.000009913709,0.0003834851],"genre_scores_gemma":[0.9984819,0.0001503746,0.00007682778,0.0004992516,0.0002066431,0.0001893636,0.0002294247,0.0000177249,0.0001484487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5982589,"threshold_uncertainty_score":0.5581329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008445836193116464,"score_gpt":0.242297483580667,"score_spread":0.2338516473875505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}