{"id":"W4212767975","doi":"10.1002/art.42098","title":"IgG Anti–Citrullinated Protein Antibody Variable Domain Glycosylation Increases Before the Onset of Rheumatoid Arthritis and Stabilizes Thereafter: A Cross‐Sectional Study Encompassing ~1,500 Samples","year":2022,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Dutch Arthritis Association; Reumatikerförbundet; ReumaNederland; Leids Universitair Medisch Centrum; Umeå Universitet; Universiteit Leiden; Vetenskapsrådet; ZonMw; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Rheumatoid arthritis; Antibody; Glycosylation; Immunology; Medicine; Immunoglobulin G; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001828951,0.0004221954,0.001119453,0.0003993874,0.001647159,0.000184982,0.0003389168,0.0001341769,0.001471675],"category_scores_gemma":[0.0005382603,0.0003623021,0.0001689214,0.0006422778,0.001198181,0.0003448244,0.0004473443,0.0006782701,0.00001119269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009295574,"about_ca_system_score_gemma":0.000440005,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007422402,"about_ca_topic_score_gemma":0.002260084,"domain_scores_codex":[0.9948128,0.001335481,0.001315651,0.0007851437,0.0009575953,0.0007932907],"domain_scores_gemma":[0.9977344,0.0005700861,0.0004514381,0.0006826043,0.0003382681,0.0002232064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001078473,0.001426557,0.9730806,0.00007104392,0.0003482908,0.0001441465,0.00248833,0.00002649123,0.003772329,0.005987991,0.00009026219,0.01148548],"study_design_scores_gemma":[0.01377134,0.004447314,0.940414,0.001053495,0.000007683941,0.008969915,0.006876869,0.0003429065,0.0008935569,0.01914538,0.003566474,0.0005111226],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754686,0.02073284,0.000206429,0.0005231765,0.0001713458,0.002293112,0.0003450317,0.0001524264,0.000107042],"genre_scores_gemma":[0.987556,0.01048084,0.0007604602,0.00006332823,0.00001931198,0.000709212,0.0003233963,0.00006996971,0.00001749102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03266666,"threshold_uncertainty_score":0.9998829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01156742764702557,"score_gpt":0.2788781652164705,"score_spread":0.267310737569445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}