{"id":"W4212771317","doi":"10.1158/1078-0432.ccr-21-0885","title":"Natural History and Characteristics of <i>ERBB2</i> -mutated Hormone Receptor–positive Metastatic Breast Cancer: A Multi-institutional Retrospective Case–control Study from AACR Project GENIE","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy; National Center for Advancing Translational Sciences; National Cancer Institute; National Institutes of Health; Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation; Unicancer; Vanderbilt University; Institut Gustave-Roussy; Puma Biotechnology; Princess Margaret Cancer Foundation; Memorial Sloan-Kettering Cancer Center; University of Texas MD Anderson Cancer Center; Cancer Prevention and Research Institute of Texas; American Association for Cancer Research","keywords":"Natural history; Retrospective cohort study; Metastatic breast cancer; Hormone; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000640267,0.000409264,0.000432129,0.001077653,0.0004519663,0.0005056062,0.0003834265,0.0003804108,0.001907],"category_scores_gemma":[0.001139389,0.0004083934,0.0003170116,0.0008283854,0.0003290695,0.0002660271,0.0004137016,0.0002705003,0.0004071211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003406475,"about_ca_system_score_gemma":0.0002414466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003466306,"about_ca_topic_score_gemma":0.002890338,"domain_scores_codex":[0.9994318,0.0001323659,0.000045834,0.0002153568,0.00009336486,0.0000811904],"domain_scores_gemma":[0.9993741,0.0001358709,0.0002296254,0.0001103258,0.00005825917,0.00009191004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002556896,0.00009878089,0.996821,0.00001752652,0.00005420494,0.0005893562,0.00008256183,0.00003010608,0.000776674,0.00001822559,0.0001569085,0.001098892],"study_design_scores_gemma":[0.00005162815,0.0002805814,0.996137,0.00000874118,0.00004876262,0.00251016,0.0001526409,0.000134898,0.0001587456,0.00001722568,0.0004943239,0.000005365323],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999102,0.0001548125,0.0001019797,0.000008520652,0.000002380177,0.00001957028,0.0003568671,0.000004159809,0.0002496405],"genre_scores_gemma":[0.99889,0.00008872515,0.0001011258,0.00001825833,0.00001042585,0.00002533238,0.0007027374,0.000003213904,0.0001601534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003466306,"threshold_uncertainty_score":0.006892264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1110384728227096,"score_gpt":0.4503884108544883,"score_spread":0.3393499380317787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}