{"id":"W4212771317","doi":"10.1158/1078-0432.ccr-21-0885","title":"Natural History and Characteristics of <i>ERBB2</i> -mutated Hormone Receptor–positive Metastatic Breast Cancer: A Multi-institutional Retrospective Case–control Study from AACR Project GENIE","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy; National Center for Advancing Translational Sciences; National Cancer Institute; National Institutes of Health; Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation; Unicancer; Vanderbilt University; Institut Gustave-Roussy; Puma Biotechnology; Princess Margaret Cancer Foundation; Memorial Sloan-Kettering Cancer Center; University of Texas MD Anderson Cancer Center; Cancer Prevention and Research Institute of Texas; American Association for Cancer Research","keywords":"Natural history; Retrospective cohort study; Metastatic breast cancer; Hormone; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.002224091,0.0003398764,0.001239523,0.000279157,0.0004717623,0.00001952462,0.0002683326,0.00008400354,0.0009104467],"category_scores_gemma":[0.0005512302,0.0002924696,0.0002059714,0.0006583034,0.001473504,0.0001790166,0.0003588285,0.00231501,0.000004702745],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004391576,"about_ca_system_score_gemma":0.002977123,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01294486,"about_ca_topic_score_gemma":0.0008010604,"domain_scores_codex":[0.9943569,0.001542869,0.001018374,0.001017484,0.001432735,0.0006316421],"domain_scores_gemma":[0.996413,0.001098059,0.0003986371,0.0004862721,0.001313362,0.000290673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.09940443,0.01144519,0.6339927,0.0003047074,0.01070359,0.00976296,0.01401524,0.00009591322,0.03400801,0.0001267403,0.003932102,0.1822084],"study_design_scores_gemma":[0.02207921,0.003461161,0.9644031,0.0001514814,0.0007030101,0.000795874,0.003716346,0.001304414,0.00009820196,0.00004895125,0.002808716,0.0004295252],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.964132,0.01973417,0.0001117586,0.0009736484,0.0008502924,0.003031576,0.01107965,0.00006226854,0.00002461596],"genre_scores_gemma":[0.995563,0.0008420459,0.0005998186,0.0003841995,0.0005582824,0.001535566,0.0001038652,0.00006529011,0.0003479705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3304105,"threshold_uncertainty_score":0.9999867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1110384728227096,"score_gpt":0.4503884108544883,"score_spread":0.3393499380317787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}