{"id":"W4212792072","doi":"10.1101/2022.02.17.480815","title":"Interaction mechanism between the HSV-1 glycoprotein B and the antimicrobial peptide Amyloid-β","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; Université de Sherbrooke","funders":"Agencia Estatal de Investigación; Canadian Institutes of Health Research; Ikerbasque, Basque Foundation for Science; Basque Center for Applied Mathematics; Eusko Jaurlaritza; Université de Sherbrooke","keywords":"Förster resonance energy transfer; Amyloid (mycology); Infectious disease (medical specialty); Intracellular; Peptide; Antimicrobial; Biology; Amyloid beta; In vitro; Neuroscience; Population; Mechanism (biology); Computational biology; Disease; Chemistry; Immunology; Cell biology; Biochemistry; Microbiology; Medicine; Philosophy; Physics; Epistemology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000190373,0.0002536013,0.0001907064,0.0001173241,0.0002651686,0.0003648401,0.000289093,0.0004416792,0.0008507477],"category_scores_gemma":[0.0002402829,0.0001285609,0.0002900361,0.00006938547,0.0003117658,0.0004467187,0.0003140123,0.0004888745,0.0003338175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003297822,"about_ca_system_score_gemma":0.0001676169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004793509,"about_ca_topic_score_gemma":0.0002184833,"domain_scores_codex":[0.9998558,0.0000273781,0.000006126896,0.00004317716,0.00003562668,0.00003198218],"domain_scores_gemma":[0.9999331,0.00002092658,0.0000162641,0.000007485092,0.000009710421,0.00001260046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005842798,0.00003191286,0.0005671174,0.00006811466,0.00001802361,0.0001485597,0.00004350815,0.0003650353,0.9956981,0.001450097,0.0000799724,0.001471126],"study_design_scores_gemma":[0.00001536796,0.0002035025,0.00313432,0.0000173171,0.00002794906,0.0005626121,0.0001381768,0.01291567,0.9795607,0.0007811264,0.00262653,0.00001678916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861984,0.002240592,0.00868143,0.0002260862,0.00005315328,0.00001883542,0.00004670112,0.00004067377,0.002494012],"genre_scores_gemma":[0.9968406,0.0004501574,0.001759699,0.00007667073,0.00000596201,0.000009980746,0.00002991645,0.000004188086,0.0008227488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008507477,"threshold_uncertainty_score":0.002846003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02029095755897844,"score_gpt":0.2653272719376151,"score_spread":0.2450363143786366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}