{"id":"W4212795244","doi":"10.1093/jcag/gwab049.034","title":"A35 DNA HYPOMETHYLATION INHIBITS TUFT CELL-DERIVED COLITIS-ASSOCIATED CANCER","year":2022,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Colorectal cancer; DNA methylation; Carcinogenesis; Colitis; Cancer research; Epigenetics; Adenomatous polyposis coli; Cancer; Biology; Sulindac; Familial adenomatous polyposis; Molecular biology; Immunology; Gene expression; Pharmacology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001334565,0.0003685596,0.0003322854,0.0005165765,0.0001591726,0.0002350941,0.0002586381,0.0003635825,0.003006253],"category_scores_gemma":[0.0001264927,0.0001364338,0.0002835277,0.000199318,0.0002586692,0.0001167809,0.0001581496,0.0008421407,0.0005351706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003702076,"about_ca_system_score_gemma":0.000297756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001901226,"about_ca_topic_score_gemma":0.003091818,"domain_scores_codex":[0.9998178,0.00002466372,0.00001630322,0.00003892185,0.0000451952,0.00005714189],"domain_scores_gemma":[0.9998176,0.00002530057,0.00005322523,0.00002102581,0.00001466115,0.0000681919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002033052,0.00006964346,0.0001345559,0.00002980991,0.000007085655,0.00001428075,0.00000998664,0.00005703916,0.9980078,0.00005032469,0.0001125333,0.001303569],"study_design_scores_gemma":[0.0000809038,0.001976273,0.004250602,0.00001368137,0.00003511401,0.0001632845,0.00003665151,0.0008025343,0.9886109,0.00004671777,0.003976944,0.000006366448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920084,0.002308446,0.001574436,0.000202917,0.00007433951,0.00005502507,0.0009909384,0.0004721827,0.002313246],"genre_scores_gemma":[0.9938043,0.0009219247,0.001003407,0.00007680123,0.00001553215,0.00004805214,0.0009443768,0.00003112048,0.00315451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003006253,"threshold_uncertainty_score":0.01005691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006980903418839663,"score_gpt":0.2278747116091165,"score_spread":0.2208938081902769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}