{"id":"W4212802010","doi":"10.1101/2022.02.17.480877","title":"Regulatory mechanisms of the dynein-2 motility by post-translational modification revealed by MD simulation","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Japan Society for the Promotion of Science; Canadian Institutes of Health Research","keywords":"Dynein; Intraflagellar transport; Cilium; Microtubule; Motility; Cell biology; Molecular motor; Chemistry; Flagellum; Kinesin; Biophysics; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002062977,0.0005112508,0.0005626584,0.0003668377,0.0005724582,0.000482178,0.0008040461,0.0007318608,0.002107243],"category_scores_gemma":[0.0006139287,0.0002773685,0.0005872594,0.0002413895,0.0006320297,0.0004663043,0.0004472764,0.0006650435,0.0001332688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007844813,"about_ca_system_score_gemma":0.0007793144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01028754,"about_ca_topic_score_gemma":0.004143167,"domain_scores_codex":[0.9999052,0.0000184184,0.000004544091,0.00001692048,0.00002013397,0.00003478489],"domain_scores_gemma":[0.9997497,0.00009740455,0.0000327862,0.0000331673,0.00003797662,0.00004893065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001586195,0.0001647977,0.003622896,0.0000790291,0.00007781314,0.0001408264,0.00006072833,0.976193,0.01291288,0.004704206,0.000409504,0.00147569],"study_design_scores_gemma":[0.00002445056,0.00002395822,0.0007695373,0.000003929956,0.000007432754,0.000005853161,0.000009847954,0.9975769,0.001001033,0.000426596,0.0001434447,0.000007018156],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983869,0.0001239676,0.01079698,0.0002067978,0.00004354597,0.00003995771,0.0003692403,0.0001437999,0.004406641],"genre_scores_gemma":[0.9961143,0.00006417432,0.003053573,0.00002884908,0.000005974518,0.00006050905,0.0002054713,0.00003494929,0.0004323666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01028754,"threshold_uncertainty_score":0.02045536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008009821075366205,"score_gpt":0.2193619226660738,"score_spread":0.2113521015907076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}