{"id":"W4212808463","doi":"10.1101/2022.02.15.480616","title":"Canonical Wnt signaling promotes formation of somatic permeability barrier for proper germ cell differentiation","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Academia Sinica","keywords":"Morphogen; Wnt signaling pathway; Cell biology; Biology; Somatic cell; Germline; Stem cell; Germ cell; Cellular differentiation; Signal transduction; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006989962,0.0002208747,0.0001428963,0.0002239384,0.0001452948,0.0003495554,0.0001029173,0.0002140575,0.00230146],"category_scores_gemma":[0.00009371981,0.0001717105,0.0001510581,0.0001020022,0.0001929078,0.0001900629,0.0003278871,0.0004390311,0.0009175714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003560065,"about_ca_system_score_gemma":0.0002813165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009793013,"about_ca_topic_score_gemma":0.001833671,"domain_scores_codex":[0.9998788,0.000009309842,0.000007762989,0.00002057842,0.00005112825,0.00003245688],"domain_scores_gemma":[0.999909,0.000007752793,0.00002339063,0.00001048705,0.0000128251,0.0000364456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002601321,0.000003447205,0.0002361913,0.00001629617,0.000001986956,0.0000665058,0.000006587553,0.00003215277,0.9986408,0.0003235512,0.0000823052,0.0005639528],"study_design_scores_gemma":[0.00001185346,0.00002052702,0.007600766,0.000005543804,0.000003893956,0.0002771668,0.00002288648,0.000946601,0.9855273,0.0001163252,0.00546402,0.000003127166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983033,0.001298739,0.006706253,0.0002116735,0.00004979839,0.00002213103,0.0008360788,0.0002613313,0.007580892],"genre_scores_gemma":[0.9864554,0.0004757445,0.002965064,0.0000583453,0.00001041226,0.00001174715,0.0007492306,0.00008723904,0.009186663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00230146,"threshold_uncertainty_score":0.007699132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01036974738441585,"score_gpt":0.2172385605432501,"score_spread":0.2068688131588342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}