{"id":"W4212808463","doi":"10.1101/2022.02.15.480616","title":"Canonical Wnt signaling promotes formation of somatic permeability barrier for proper germ cell differentiation","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Academia Sinica","keywords":"Morphogen; Wnt signaling pathway; Cell biology; Biology; Somatic cell; Germline; Stem cell; Germ cell; Cellular differentiation; Signal transduction; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006527756,0.000300631,0.0003294017,0.00008341563,0.0001742906,0.00003290867,0.0002603383,0.0004349564,0.00004554007],"category_scores_gemma":[0.0001770696,0.0002955725,0.0001816758,0.00009163774,0.00008069327,0.00001224084,0.0003515652,0.000203333,0.000002034326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001279237,"about_ca_system_score_gemma":0.0005465706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006469836,"about_ca_topic_score_gemma":0.000002918465,"domain_scores_codex":[0.9981701,0.0001899776,0.0005737544,0.0005975311,0.0001943492,0.0002742778],"domain_scores_gemma":[0.9985801,0.00002713001,0.0005047301,0.0005082544,0.0002972816,0.00008247721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008044307,0.0001359204,0.008865875,0.0008484594,0.00006358231,3.624758e-7,0.00002097786,0.0001479927,0.989776,0.00002372047,0.00003165022,0.000005074495],"study_design_scores_gemma":[0.0004018024,0.0001446174,0.04011928,0.00005522807,0.00007221948,1.461504e-8,0.000006036449,0.0006302421,0.9576944,0.000009133193,0.0005281527,0.0003389055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928389,0.0004021611,0.004739203,0.00004565343,0.0003708871,0.00133257,0.0002326679,0.00003326263,0.000004670719],"genre_scores_gemma":[0.995586,0.00003703864,0.003548851,0.00003367538,0.000138283,0.0005602745,0.00003693725,0.00004383282,0.00001504135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03208157,"threshold_uncertainty_score":0.9999496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01036974738441585,"score_gpt":0.2172385605432501,"score_spread":0.2068688131588342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}