{"id":"W4212810392","doi":"10.1093/rheumatology/keac112","title":"Competitive binding of transcription factors underlies flexibility of T peripheral helper cells and T follicular helper cells in SLE","year":2022,"lang":"en","type":"article","venue":"Lara D. Veeken","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Natural Science Foundation of China; Dalhousie Medical Research Foundation","keywords":"Cytokine; Immunology; STAT5; Biology; Flow cytometry; STAT protein; IL-2 receptor; Immune system; Molecular biology; Cell biology; STAT3; T cell; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002145749,0.0002775452,0.0002190973,0.0002411084,0.000158519,0.0003109035,0.0002000131,0.0002341936,0.002160088],"category_scores_gemma":[0.0002124708,0.0001500431,0.0002276373,0.0001123624,0.0002897103,0.0002065357,0.0002807407,0.0003899255,0.0003430574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001966034,"about_ca_system_score_gemma":0.00009435017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001952496,"about_ca_topic_score_gemma":0.0002470668,"domain_scores_codex":[0.9997491,0.00004333665,0.00001779747,0.00007343212,0.00005383682,0.00006250329],"domain_scores_gemma":[0.9998651,0.00002659453,0.0000476683,0.0000136138,0.00001414478,0.00003289854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002637631,0.00001955188,0.007380139,0.00006222932,0.00001080602,0.0002122965,0.0000712879,0.00006645163,0.9880202,0.0001735886,0.00004973552,0.003669909],"study_design_scores_gemma":[0.0001815355,0.002179874,0.3314286,0.00005568298,0.0001370634,0.008526673,0.0007163154,0.003400568,0.6444836,0.001795263,0.007061243,0.00003356449],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948488,0.002422637,0.00168153,0.00005607969,0.000009964318,0.00001142752,0.0001186502,0.00004425734,0.0008066812],"genre_scores_gemma":[0.998696,0.0002757453,0.0004462193,0.00002212508,0.00001260457,0.000008685234,0.00008868516,0.000004972925,0.000444902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002160088,"threshold_uncertainty_score":0.007226288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01796421662005637,"score_gpt":0.2283961600409528,"score_spread":0.2104319434208964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}