{"id":"W4212819300","doi":"10.1093/jcag/gwab049.144","title":"A145 EFFICACY AND SAFETY OF UPADACITINIB MAINTENANCE THERAPY IN PATIENTS WITH MODERATELY TO SEVERELY ACTIVE ULCERATIVE COLITIS: RESULTS FROM A RANDOMIZED PHASE 3 STUDY","year":2022,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Clinical endpoint; Maintenance therapy; Medicine; Ulcerative colitis; Internal medicine; Gastroenterology; Placebo; Clinical trial; Phases of clinical research; Surgery; Randomized controlled trial; Adverse effect; Chemotherapy; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003438769,0.0009140766,0.002740194,0.0002969339,0.0004908653,0.0009713669,0.0006819849,0.001080886,0.003129309],"category_scores_gemma":[0.00203511,0.0004600254,0.002341353,0.0004719345,0.0008201727,0.0008075017,0.0003962106,0.00172146,0.0004246467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005980739,"about_ca_system_score_gemma":0.001118523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005112516,"about_ca_topic_score_gemma":0.001269838,"domain_scores_codex":[0.9984714,0.0009096201,0.000123045,0.0001922245,0.0001468725,0.0001567093],"domain_scores_gemma":[0.9981014,0.0004620423,0.0005640393,0.000202005,0.0001477958,0.0005227024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9492855,0.008015032,0.003708277,0.0006838007,0.00251206,0.00008238172,0.00007336194,0.0002739233,0.007305966,0.00005272072,0.0007281308,0.02727891],"study_design_scores_gemma":[0.7905314,0.1864404,0.01838734,0.00005470568,0.002010401,0.0001372027,0.00003467158,0.0004990949,0.0009856694,0.00009616311,0.0007935341,0.00002935268],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992047,0.003861933,0.000484595,0.0002411089,0.00009003602,0.001919401,0.0006145617,0.00004800666,0.000693505],"genre_scores_gemma":[0.994864,0.001146892,0.0008961527,0.0004299097,0.000145442,0.001273462,0.0007661696,0.00001026889,0.0004676632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003438769,"threshold_uncertainty_score":0.01818615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005375459870756411,"score_gpt":0.2222250554753932,"score_spread":0.2168495956046368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}