{"id":"W4212820686","doi":"10.1093/jcag/gwab049.020","title":"A21 OVEREXPRESSION OF <i>ASCL2</i> ALTERS DIFFERENTIATION IN ESOPHAGEAL ORGANOIDS","year":2022,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Organoid; Stem cell; Cell biology; Biology; Wnt signaling pathway; Stem cell marker; Cellular differentiation; Immunostaining; Immunology; Signal transduction; Immunohistochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001773294,0.0003478538,0.0002136637,0.0002955026,0.0001685368,0.000391042,0.0002135869,0.0003490853,0.001962299],"category_scores_gemma":[0.0001095465,0.0001618665,0.0003544468,0.000200239,0.0002707872,0.0002568112,0.0002387073,0.0007565201,0.0009414715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003074964,"about_ca_system_score_gemma":0.0001448134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009141048,"about_ca_topic_score_gemma":0.0006813636,"domain_scores_codex":[0.9997393,0.00003830607,0.00005499502,0.00006235699,0.00006096311,0.0000440769],"domain_scores_gemma":[0.9997348,0.00004574413,0.00006965621,0.00004287709,0.00002110554,0.00008586568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003780192,0.00001227909,0.00007419094,0.00001168034,0.000002508184,0.00004028033,0.000007654845,0.00002777918,0.9995449,0.00003525486,0.00003651323,0.000169194],"study_design_scores_gemma":[0.000005022516,0.0001240326,0.002447382,0.00000367156,0.000008269365,0.0001576129,0.00003353302,0.0006314621,0.9951525,0.00001897918,0.001414507,0.000003118712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911234,0.0007741394,0.00351245,0.0001753774,0.00006954336,0.00003004597,0.001753761,0.0002744584,0.002286652],"genre_scores_gemma":[0.9898298,0.0004732654,0.001897872,0.00008121302,0.00001065055,0.00005007318,0.001498081,0.00007292924,0.006086058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001962299,"threshold_uncertainty_score":0.006564558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002948373350953701,"score_gpt":0.1902154710894744,"score_spread":0.1872670977385207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}