{"id":"W4212821853","doi":"10.1200/jco.2022.40.6_suppl.tps200","title":"A randomized, controlled, phase 3 study of darolutamide in addition to androgen deprivation therapy (ADT) versus ADT alone in metastatic hormone-sensitive prostate cancer (ARANOTE).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Enzalutamide; Prostate cancer; Androgen deprivation therapy; Internal medicine; Oncology; Docetaxel; Adverse effect; Placebo; Tolerability; Clinical endpoint; Abiraterone acetate; Randomized controlled trial; Cancer; Androgen receptor; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003497913,0.002509736,0.003576866,0.0007711811,0.0007002762,0.001530913,0.001569816,0.002265252,0.01255238],"category_scores_gemma":[0.003098197,0.001142391,0.002053632,0.0007579131,0.00166959,0.001727169,0.0005944757,0.005306127,0.0018394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009849089,"about_ca_system_score_gemma":0.002015968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001226746,"about_ca_topic_score_gemma":0.003009323,"domain_scores_codex":[0.9986641,0.0007561488,0.00005914862,0.0002478265,0.0001005744,0.0001721794],"domain_scores_gemma":[0.9979056,0.0006189512,0.0004097087,0.0001714077,0.0001691615,0.0007252163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9841409,0.009796867,0.0001883781,0.0002500325,0.0003549632,0.00001954156,0.00002361906,0.0001340919,0.001199212,0.00006218095,0.000464818,0.00336536],"study_design_scores_gemma":[0.9466737,0.05207006,0.0004584568,0.00001073052,0.0001494443,0.00001319458,0.00001019208,0.0001764427,0.0001007503,0.00005847306,0.0002704396,0.000008104647],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9558302,0.003977777,0.002010467,0.001227534,0.002177975,0.02530738,0.004241118,0.000489729,0.004737988],"genre_scores_gemma":[0.9555662,0.002939015,0.004850581,0.002721121,0.001237109,0.02270827,0.003203671,0.00007645658,0.006697591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01255238,"threshold_uncertainty_score":0.04199189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1408623413131093,"score_gpt":0.5041841219842379,"score_spread":0.3633217806711286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}