{"id":"W4212834341","doi":"10.1136/jitc-2021-003490","title":"Oncolytic adenovirus decreases the proportion of TIM-3+ subset of tumor-infiltrating CD8+ T cells with correlation to improved survival in patients with cancer","year":2022,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Etelä-Savon Rahasto; Novo Nordisk Fonden; K. Albin Johanssons Stiftelse; Syöpäjärjestöt; Päivikki ja Sakari Sohlbergin Säätiö; Novo Nordisk; Jane ja Aatos Erkon Säätiö; Suomen Kulttuurirahasto; Suomen Lääketieteen Säätiö; Suomalais-Norjalainen Lääketieteen Säätiö; Helsingin Yliopisto","keywords":"Oncolytic virus; Oncolytic adenovirus; Immunotherapy; Medicine; CD8; Immune checkpoint; Melanoma; Cancer; Immune system; Cancer research; Cytotoxic T cell; Cancer immunotherapy; Tumor-infiltrating lymphocytes; T cell; Immunology; Oncology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001275965,0.0001243093,0.0001580382,0.0001216921,0.00006508623,0.0001534498,0.00005888101,0.0001136128,0.0008108396],"category_scores_gemma":[0.0002084211,0.00006334054,0.0001005197,0.0001043665,0.000105021,0.00009828134,0.00007374223,0.0002421885,0.0001200284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001082267,"about_ca_system_score_gemma":0.00008637535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001703767,"about_ca_topic_score_gemma":0.000184158,"domain_scores_codex":[0.9999497,0.00001053435,0.000005206173,0.00001259662,0.000007825923,0.00001404307],"domain_scores_gemma":[0.9998444,0.00003522647,0.00005846574,0.0000138267,0.00001428938,0.00003363924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005989431,0.0006061607,0.1372511,0.0001016606,0.00005877308,0.0001143505,0.0000822413,0.0004169442,0.8206159,0.00006782827,0.000318944,0.03437658],"study_design_scores_gemma":[0.0001826363,0.01211755,0.7012863,0.000009458925,0.0001532134,0.0017157,0.0001492282,0.002131899,0.2790888,0.0001053866,0.003049238,0.00001063047],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990897,0.0004370257,0.0002057559,0.00001715541,0.000002833993,0.000005925896,0.00008491674,0.000009853534,0.0001467531],"genre_scores_gemma":[0.9992537,0.0001330348,0.0002072878,0.00001168109,0.000004191272,0.000006933356,0.0001696887,0.000001835054,0.0002116804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008108396,"threshold_uncertainty_score":0.002712488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009075243039969082,"score_gpt":0.2547694869841357,"score_spread":0.2456942439441666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}