{"id":"W4212834341","doi":"10.1136/jitc-2021-003490","title":"Oncolytic adenovirus decreases the proportion of TIM-3+ subset of tumor-infiltrating CD8+ T cells with correlation to improved survival in patients with cancer","year":2022,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Etelä-Savon Rahasto; Novo Nordisk Fonden; K. Albin Johanssons Stiftelse; Syöpäjärjestöt; Päivikki ja Sakari Sohlbergin Säätiö; Novo Nordisk; Jane ja Aatos Erkon Säätiö; Suomen Kulttuurirahasto; Suomen Lääketieteen Säätiö; Suomalais-Norjalainen Lääketieteen Säätiö; Helsingin Yliopisto","keywords":"Oncolytic virus; Oncolytic adenovirus; Immunotherapy; Medicine; CD8; Immune checkpoint; Melanoma; Cancer; Immune system; Cancer research; Cytotoxic T cell; Cancer immunotherapy; Tumor-infiltrating lymphocytes; T cell; Immunology; Oncology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006155395,0.0002418113,0.0006023083,0.0001986753,0.0002878109,0.00001071738,0.0003203973,0.00009513978,0.0008937742],"category_scores_gemma":[0.00002775653,0.0001586595,0.0001392183,0.0004038237,0.0002056546,0.0001096194,0.00003598057,0.0004663735,5.669472e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003251685,"about_ca_system_score_gemma":0.0007965679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002849075,"about_ca_topic_score_gemma":0.0006462371,"domain_scores_codex":[0.9980574,0.0002601519,0.0008484185,0.0002582591,0.0001974325,0.0003783906],"domain_scores_gemma":[0.9978656,0.0001635916,0.001210094,0.0002462415,0.0004854969,0.00002898877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0369782,0.000905513,0.5035728,0.0001286849,0.001389527,0.000001931784,0.005186881,0.1438071,0.2762336,0.00005154858,0.0007773501,0.03096697],"study_design_scores_gemma":[0.05316925,0.03984179,0.4774841,0.001309368,0.0008385862,0.000154028,0.01112525,0.002649916,0.3777794,0.0001669833,0.03383645,0.001644882],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948078,0.002844508,0.0002652386,0.0001403426,0.0004167003,0.001152244,0.0003320395,0.000008412587,0.00003265307],"genre_scores_gemma":[0.9987031,0.0002147352,0.0001379136,0.0001767896,0.00004941666,0.000313091,0.00004636186,0.00004078795,0.0003177536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1411571,"threshold_uncertainty_score":0.9786201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009075243039969082,"score_gpt":0.2547694869841357,"score_spread":0.2456942439441666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}