{"id":"W4212837652","doi":"10.1101/2022.02.18.481058","title":"Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Medical Center, University of Pittsburgh; National Institutes of Health; Genome British Columbia; University of Pittsburgh; Howard Hughes Medical Institute","keywords":"Panning (audio); Neutralization; Virology; Epitope; Titer; Antibody; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Biology; Computational biology; Chemistry; Virus; Coronavirus disease 2019 (COVID-19); Genetics; Medicine; Disease; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001538721,0.0002288023,0.0001084201,0.00008039515,0.00006628568,0.0001654192,0.0001034043,0.0002202745,0.001088567],"category_scores_gemma":[0.00009470939,0.00005371246,0.0001363719,0.0000502951,0.0001121931,0.00008012597,0.0001408598,0.0003297602,0.0002407032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001491848,"about_ca_system_score_gemma":0.00008040872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003872383,"about_ca_topic_score_gemma":0.0004422193,"domain_scores_codex":[0.9999247,0.00001546437,0.000004354253,0.00001350824,0.00001719816,0.00002483389],"domain_scores_gemma":[0.9999624,0.00001077675,0.00000641226,0.000005924933,0.000004119563,0.00001025678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000812137,0.00003194915,0.0001717139,0.00001304368,0.000003732953,0.0000296487,0.000009792745,0.0001082186,0.9982516,0.00005051998,0.00005051044,0.001198054],"study_design_scores_gemma":[0.00004110674,0.0008434069,0.003849728,0.0000053104,0.000007702271,0.0006351481,0.00002070647,0.001415539,0.9900441,0.0000602798,0.00307385,0.000003156526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958459,0.0003736732,0.00246974,0.000046241,0.00001174689,0.00001794916,0.0001456053,0.00002360475,0.001065544],"genre_scores_gemma":[0.9962692,0.0001514553,0.001906209,0.00005717895,0.000008926304,0.000009511982,0.0003483351,0.000007274551,0.001241939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001088567,"threshold_uncertainty_score":0.003641605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04318662196518128,"score_gpt":0.3168211914301471,"score_spread":0.2736345694649659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}