{"id":"W4212838987","doi":"10.1186/s13075-022-02739-4","title":"TLC599 in patients with osteoarthritis of the knee: a phase IIa, randomized, placebo-controlled, dose-finding study","year":2022,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Osteoarthritis; Placebo; WOMAC; Rheumatology; Randomized controlled trial; Visual analogue scale; Knee pain; Placebo-controlled study; Anesthesia; Internal medicine; Double blind","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002594043,0.001273762,0.003187628,0.0005177046,0.0005114895,0.001018333,0.0009591911,0.00216352,0.006401237],"category_scores_gemma":[0.001797248,0.0007679668,0.001583521,0.0005914267,0.0009494813,0.0008250995,0.000323745,0.001634515,0.001315293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004980467,"about_ca_system_score_gemma":0.001402088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004834212,"about_ca_topic_score_gemma":0.001162094,"domain_scores_codex":[0.9991683,0.0003870916,0.00009678453,0.0001385499,0.000111335,0.00009786284],"domain_scores_gemma":[0.9988444,0.0002977721,0.0003366794,0.00009049366,0.0001396967,0.0002908587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9484268,0.0174718,0.0008748447,0.001884984,0.001059283,0.00007127564,0.00007538906,0.000208916,0.01182848,0.00007481323,0.0006989656,0.01732435],"study_design_scores_gemma":[0.9104139,0.08690825,0.001367318,0.00004414194,0.0003362171,0.00002998094,0.00001227773,0.0001220791,0.0003540051,0.00002840881,0.0003734056,0.00001004368],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9734784,0.01051917,0.001120875,0.0008526166,0.0006100397,0.009801169,0.001176276,0.0001674309,0.002274055],"genre_scores_gemma":[0.9769782,0.007185461,0.002417146,0.002024615,0.0006873345,0.007007884,0.001200642,0.00003365094,0.002465134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006401237,"threshold_uncertainty_score":0.02141428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02818600007304968,"score_gpt":0.3273851910559272,"score_spread":0.2991991909828775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}