{"id":"W4212868305","doi":"10.1089/hum.2021.287","title":"Global Seroprevalence of Pre-existing Immunity Against AAV5 and Other AAV Serotypes in People with Hemophilia A","year":2022,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"NovAtel (Canada)","funders":"","keywords":"Seroprevalence; Medicine; Serotype; Antibody; Immunity; Titer; Immunology; Internal medicine; Virology; Immune system; Serology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006908868,0.0003270856,0.000308175,0.001075776,0.0003094937,0.0005905756,0.0002289265,0.0004500368,0.001405602],"category_scores_gemma":[0.001027273,0.0003377813,0.0004392712,0.0008703367,0.0004614229,0.0007031746,0.0004678118,0.0004351062,0.0002452254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000188662,"about_ca_system_score_gemma":0.0001346503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003719156,"about_ca_topic_score_gemma":0.00385218,"domain_scores_codex":[0.9996133,0.000123131,0.00005651042,0.00009317703,0.00005783767,0.00005611976],"domain_scores_gemma":[0.9991788,0.0001613355,0.0003830082,0.00006823143,0.0000985987,0.0001098638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004844525,0.0000239764,0.9977887,0.00002350181,0.00003533666,0.0000257243,0.0002437903,0.00002070256,0.0002547016,0.00001242439,0.0000634412,0.00145927],"study_design_scores_gemma":[0.000003438043,0.0001312464,0.9989919,0.00001335033,0.00002551067,0.0002146028,0.0003824468,0.00004913822,0.00005487341,0.00001671122,0.0001130051,0.000003800913],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986421,0.0003635949,0.00008120752,0.00002605513,0.000003810647,0.000009434843,0.0003331242,0.000007499464,0.0005332306],"genre_scores_gemma":[0.9993475,0.0002091796,0.0001048451,0.00003119629,0.000006204068,0.00001121411,0.0001820652,0.000001426145,0.0001063769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003719156,"threshold_uncertainty_score":0.007395029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02750703600293573,"score_gpt":0.3139342164974082,"score_spread":0.2864271804944724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}