{"id":"W4212876904","doi":"10.1038/s41419-022-04591-5","title":"Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes","year":2022,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; Université de Montréal; Université Laval; Centre Hospitalier de l’Université de Montréal; Centre hospitalier universitaire de Québec; Institute for Research in Immunology and Cancer; Translational Research in Oncology","funders":"Institute of Nutrition, Metabolism and Diabetes; Université de Montréal; Government of Canada; Fonds de Recherche du Québec - Santé; Kidney Foundation of Canada; Natural Sciences and Engineering Research Council of Canada; Fondation Jean-Louis Lévesque; Canadian Institutes of Health Research; Genome Canada","keywords":"Microvesicles; Cell biology; Apoptosis; Biogenesis; Caspase; Chemistry; Caspase 3; Caspase 8; Biology; Programmed cell death; microRNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001253401,0.0001563843,0.000141651,0.00003753279,0.0002740361,0.00002460669,0.0001333721,0.00003375426,0.00002712154],"category_scores_gemma":[0.0000815677,0.000129299,0.00007961244,0.00005932395,0.0002092214,0.000004719553,0.0002486811,0.00006052861,7.485668e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006240467,"about_ca_system_score_gemma":0.0001098146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003171096,"about_ca_topic_score_gemma":0.000001601495,"domain_scores_codex":[0.9990484,0.0001319958,0.0001692268,0.0003319056,0.0001247597,0.0001937282],"domain_scores_gemma":[0.9991089,0.00004181957,0.00007911913,0.0003812366,0.00002540241,0.00036353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001605496,0.0004589298,0.1682896,0.0003648375,0.0001903036,0.0001204292,0.000136996,0.0001367035,0.8229401,0.0008068365,0.0009057213,0.004044105],"study_design_scores_gemma":[0.01845168,0.002077167,0.7184614,0.00006503045,0.00375097,0.0002284738,0.002663033,0.005889993,0.214499,0.005161188,0.0261757,0.002576385],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9026695,0.09645359,0.0000519749,0.0001956854,0.0000374936,0.000242919,0.0002748019,0.00000849639,0.00006545922],"genre_scores_gemma":[0.9977612,0.001331538,0.0000506619,0.0003907289,0.00003896925,0.00005963443,0.00005516901,0.00002042847,0.0002915993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6084411,"threshold_uncertainty_score":0.5272661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004918384888852491,"score_gpt":0.1979351104050636,"score_spread":0.1930167255162111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}