{"id":"W4212876904","doi":"10.1038/s41419-022-04591-5","title":"Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes","year":2022,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; Université de Montréal; Université Laval; Centre Hospitalier de l’Université de Montréal; Centre hospitalier universitaire de Québec; Institute for Research in Immunology and Cancer; Translational Research in Oncology","funders":"Institute of Nutrition, Metabolism and Diabetes; Université de Montréal; Government of Canada; Fonds de Recherche du Québec - Santé; Kidney Foundation of Canada; Natural Sciences and Engineering Research Council of Canada; Fondation Jean-Louis Lévesque; Canadian Institutes of Health Research; Genome Canada","keywords":"Microvesicles; Cell biology; Apoptosis; Biogenesis; Caspase; Chemistry; Caspase 3; Caspase 8; Biology; Programmed cell death; microRNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002647644,0.0003878959,0.000369051,0.0002473767,0.000190752,0.000618167,0.0002171753,0.0004063943,0.0007132245],"category_scores_gemma":[0.0002427317,0.0001327452,0.0004034165,0.000154916,0.0003751838,0.0006327233,0.0004755768,0.0005469413,0.0003599063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004982235,"about_ca_system_score_gemma":0.000270683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002120119,"about_ca_topic_score_gemma":0.0002743029,"domain_scores_codex":[0.9996736,0.00006352789,0.00003923494,0.00007868535,0.00006053861,0.00008441536],"domain_scores_gemma":[0.9997528,0.00003479137,0.00008970095,0.00002479858,0.00004888817,0.00004899594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003168736,0.00002434491,0.0006939674,0.00005178273,0.000005740307,0.0001323744,0.00003958293,0.00008538547,0.9969569,0.0003301491,0.00003286473,0.001330033],"study_design_scores_gemma":[0.00003346386,0.000129015,0.01029989,0.000009265854,0.00001313211,0.0004432398,0.0001031027,0.002789969,0.9841357,0.0003772385,0.001656839,0.000009122138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875052,0.003376922,0.007814349,0.00008376212,0.00003056465,0.00003049224,0.0002147849,0.00007630578,0.0008676393],"genre_scores_gemma":[0.9962556,0.000653944,0.001867457,0.000025302,0.000007248233,0.00001815238,0.0001353207,0.00001303517,0.001023902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007132245,"threshold_uncertainty_score":0.003614843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004918384888852491,"score_gpt":0.1979351104050636,"score_spread":0.1930167255162111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}