{"id":"W4212881292","doi":"10.1101/2022.02.15.480604","title":"The impact of hyperglycemia upon BeWo trophoblast cell metabolic function: A multi-OMICS and functional metabolic analysis","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Gestational Diabetes Research and Management","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Victoria Hospital; London Health Sciences Centre; The Metabolomics Innovation Centre; Lawson Health Research Institute; University of Alberta; Western University","funders":"National Institutes of Health; Genome Canada","keywords":"Metabolome; Syncytiotrophoblast; Endocrinology; Biology; Internal medicine; Trophoblast; Cytotrophoblast; Glycogen; Placenta; Transcriptome; Biochemistry; Fetus; Medicine; Metabolite; Gene expression; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004676667,0.0004693645,0.0006625882,0.001025562,0.0003992336,0.001019282,0.0001775817,0.0003451977,0.00124837],"category_scores_gemma":[0.0003257817,0.0001723129,0.0006815792,0.00137239,0.0002183062,0.0003203187,0.0005074532,0.0006499977,0.0003522273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003007987,"about_ca_system_score_gemma":0.0004496929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001331924,"about_ca_topic_score_gemma":0.00210565,"domain_scores_codex":[0.9997416,0.00002901057,0.00002108421,0.00008229227,0.00008314954,0.00004277862],"domain_scores_gemma":[0.9998634,0.00003213134,0.00003180825,0.00001476281,0.0000415142,0.00001640487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006321708,0.00006178597,0.02429737,0.0006078107,0.0001708864,0.0002917423,0.000203281,0.0006546884,0.9576264,0.0002847825,0.0007082091,0.01446089],"study_design_scores_gemma":[0.00005204861,0.0006825098,0.5724415,0.000246173,0.0008521558,0.001228523,0.001470917,0.01112056,0.3845275,0.001752211,0.02550293,0.0001230866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9404953,0.008892812,0.01841225,0.0005147169,0.0001252991,0.0001849535,0.0278263,0.0003050891,0.003243155],"genre_scores_gemma":[0.9330692,0.007153352,0.02572822,0.0006520152,0.00006173507,0.0005026049,0.02870593,0.0001275078,0.003999425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001331924,"threshold_uncertainty_score":0.004176199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01688277044017291,"score_gpt":0.2539713525805029,"score_spread":0.23708858214033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}