{"id":"W4212882036","doi":"10.3389/fcimb.2022.847539","title":"Novel Molecular Therapeutics Targeting Signaling Pathway to Control Hepatitis B Viral Infection","year":2022,"lang":"en","type":"review","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Natural Science Foundation of China","keywords":"Biology; Viral replication; Signal transduction; Hepatitis B virus; Genome instability; Cell biology; Virology; DNA damage; Virus; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000260521,0.0005951265,0.000901241,0.001375083,0.0001724748,0.0005356373,0.0005324921,0.0006359951,0.002925949],"category_scores_gemma":[0.0002864106,0.0001775553,0.0004501098,0.0008783236,0.0002438259,0.0006969195,0.0003618253,0.001448027,0.001249396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003341639,"about_ca_system_score_gemma":0.0004714859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003639559,"about_ca_topic_score_gemma":0.0006676809,"domain_scores_codex":[0.999915,0.0000132328,0.00001090493,0.0000166552,0.00003289344,0.00001130329],"domain_scores_gemma":[0.999928,0.00003166811,0.00001065291,0.000002749855,0.00001978152,0.000007178411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001092978,0.0001772479,0.0001381244,0.0228407,0.0001052253,0.0002523851,0.00006564785,0.0004872083,0.01136109,0.004984913,0.02024713,0.9392312],"study_design_scores_gemma":[0.00004133383,0.0002473127,0.0008351938,0.002321698,0.0001526728,0.001291378,0.00004054697,0.0001883806,0.002674187,0.001623345,0.9905643,0.00001972434],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004405809,0.9972149,0.0002678489,0.0001839858,0.0002373824,0.00001026342,0.00002696621,0.00001389565,0.001604163],"genre_scores_gemma":[0.001635554,0.9968565,0.0003212268,0.000186424,0.0001214696,0.00001342796,0.00004516615,0.000002060684,0.0008182554],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002925949,"threshold_uncertainty_score":0.009788334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02268537129787525,"score_gpt":0.2713259989828153,"score_spread":0.2486406276849401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}