{"id":"W4212882036","doi":"10.3389/fcimb.2022.847539","title":"Novel Molecular Therapeutics Targeting Signaling Pathway to Control Hepatitis B Viral Infection","year":2022,"lang":"en","type":"review","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Natural Science Foundation of China","keywords":"Biology; Viral replication; Signal transduction; Hepatitis B virus; Genome instability; Cell biology; Virology; DNA damage; Virus; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005755412,0.0005118437,0.001896362,0.0007513853,0.0002342769,0.00002710746,0.00007456154,0.0005009965,0.00009767609],"category_scores_gemma":[0.0001350612,0.0004923549,0.0003949299,0.0004638594,0.0001133711,0.00005524531,0.0001321232,0.0009066335,0.00001641242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006061441,"about_ca_system_score_gemma":0.0001730823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00181526,"about_ca_topic_score_gemma":0.0001305051,"domain_scores_codex":[0.9975445,0.000374713,0.000825704,0.0006718062,0.00009177295,0.000491458],"domain_scores_gemma":[0.9992036,0.00009737094,0.0003028842,0.0002313782,0.00006656087,0.00009825832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001026625,0.0005255848,0.05426709,0.00780644,0.00213291,0.000183507,0.0004534939,0.00009373882,0.09441925,0.0000741449,0.001906502,0.8380347],"study_design_scores_gemma":[0.0009277468,0.0005020701,0.00005430769,0.0008855243,0.0007057193,0.0001619513,0.000006958649,0.000040482,0.001065981,0.00001622018,0.9951864,0.0004466454],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004794264,0.9195064,0.07103834,0.00003011731,0.002674922,0.001598478,0.0001410663,0.00008553926,0.0001309317],"genre_scores_gemma":[0.003122061,0.9933701,0.001561905,0.0006308902,0.0002177259,0.0003169321,0.0005922096,0.00009115973,0.00009702963],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9932799,"threshold_uncertainty_score":0.9997528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02268537129787525,"score_gpt":0.2713259989828153,"score_spread":0.2486406276849401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}