{"id":"W4212891520","doi":"10.1039/d1md00371b","title":"RpoN-Based stapled peptides with improved DNA binding suppress <i>Pseudomonas aeruginosa</i> virulence","year":2022,"lang":"en","type":"article","venue":"RSC Medicinal Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; University of Ottawa","keywords":"rpoN; Biology; DNA; Pseudomonas aeruginosa; Sigma factor; Peptide; Virulence; Escherichia coli; DNA-binding protein; Binding site; Microbiology; Biochemistry; Transcription factor; Promoter; Gene; Bacteria; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001180604,0.0004118715,0.0001777941,0.00009703782,0.00005592033,0.0001759196,0.0001558451,0.0003120658,0.001352685],"category_scores_gemma":[0.0001491154,0.00009668887,0.0001362941,0.0001005601,0.0001474448,0.0001861407,0.000122988,0.0004466191,0.0003405102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001471572,"about_ca_system_score_gemma":0.000115039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001630645,"about_ca_topic_score_gemma":0.0002834107,"domain_scores_codex":[0.9998904,0.00002020334,0.000007731739,0.00001948685,0.00002807846,0.0000339287],"domain_scores_gemma":[0.9999225,0.00001315908,0.00002896362,0.000004870958,0.00001143184,0.00001902748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008403115,0.00001581222,0.00002969449,0.00003082696,0.00000277989,0.00003127448,0.000004018786,0.000131031,0.9983908,0.00004128692,0.00003914586,0.001199432],"study_design_scores_gemma":[0.00001425087,0.0004415017,0.0006500897,0.000004622892,0.000007804701,0.000146591,0.000006094234,0.0005095329,0.9964784,0.00001862807,0.001716385,0.000006101113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872902,0.001791307,0.007374439,0.00008673763,0.00008001298,0.00005424513,0.0003099039,0.0001231827,0.002889883],"genre_scores_gemma":[0.9878342,0.0007220269,0.008181076,0.000138327,0.00001441901,0.0000393471,0.0004465619,0.00002833714,0.00259581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001352685,"threshold_uncertainty_score":0.004525244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007319680176748496,"score_gpt":0.2028447973716886,"score_spread":0.1955251171949401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}