{"id":"W4212891520","doi":"10.1039/d1md00371b","title":"RpoN-Based stapled peptides with improved DNA binding suppress <i>Pseudomonas aeruginosa</i> virulence","year":2022,"lang":"en","type":"article","venue":"RSC Medicinal Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; University of Ottawa","keywords":"rpoN; Biology; DNA; Pseudomonas aeruginosa; Sigma factor; Peptide; Virulence; Escherichia coli; DNA-binding protein; Binding site; Microbiology; Biochemistry; Transcription factor; Promoter; Gene; Bacteria; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002722189,0.0003253487,0.0004161365,0.00005376657,0.000653385,0.00002418923,0.0004134592,0.0001356903,0.003595223],"category_scores_gemma":[0.00004681467,0.0002806524,0.0001130601,0.0001827552,0.0005129908,0.00008889085,0.0001827062,0.0007984229,0.00003603666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001266276,"about_ca_system_score_gemma":0.0002638535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001677962,"about_ca_topic_score_gemma":0.000006647645,"domain_scores_codex":[0.9983869,0.00008925269,0.0003016711,0.0005085885,0.0001164584,0.0005971369],"domain_scores_gemma":[0.9990654,0.0002142159,0.0002233786,0.0003779664,0.00005568124,0.00006336576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006782883,0.0001392868,0.0005784543,0.000139065,0.0001029723,0.00005261941,0.0002013443,0.00004330406,0.9927042,0.00001523495,0.005010002,0.0003352679],"study_design_scores_gemma":[0.002230509,0.0002840515,0.00009262922,0.00009391234,0.00008965228,0.0003226546,0.003063303,0.00004472459,0.9808621,0.00001281874,0.01251387,0.0003897087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951327,0.0005054166,0.000140207,0.0004775683,0.0002800599,0.0002055739,0.0002267518,0.0001666868,0.002865035],"genre_scores_gemma":[0.9926337,0.00001535589,0.0001294614,0.0005010465,0.00009945331,0.00007717489,0.0004386613,0.00003811873,0.00606704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01184199,"threshold_uncertainty_score":0.9999645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007319680176748496,"score_gpt":0.2028447973716886,"score_spread":0.1955251171949401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}