{"id":"W4212891972","doi":"10.26508/lsa.202101103","title":"Human immunodeficiency virus type 1 impairs sumoylation","year":2022,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"York University; Gilead Sciences; European Molecular Biology Organization","keywords":"SUMO protein; Biology; Immune system; Intrinsic immunity; Viral replication; Jurkat cells; Cell biology; Virology; SAMHD1; Virus; T cell; Immunity; Immunology; Ubiquitin; Genetics; Gene; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000152061,0.0004330916,0.0002046358,0.0001966797,0.0001755357,0.0003190728,0.0002106961,0.0003331203,0.002707086],"category_scores_gemma":[0.000102542,0.0001589609,0.0002260097,0.000141593,0.000191221,0.0001991488,0.0001865787,0.0005060331,0.0005344254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002178745,"about_ca_system_score_gemma":0.0001970052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006118871,"about_ca_topic_score_gemma":0.0006797839,"domain_scores_codex":[0.9998866,0.00002296184,0.0000130334,0.00002025502,0.00002328923,0.0000339487],"domain_scores_gemma":[0.9999032,0.0000166805,0.00002110935,0.00001399523,0.000005979192,0.00003911306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002470527,0.0001404196,0.0003258913,0.00002677914,0.000007629435,0.0001019603,0.00001390141,0.00006434945,0.9976369,0.0002112112,0.00009142082,0.001132573],"study_design_scores_gemma":[0.00005808371,0.001195399,0.01681283,0.00001542037,0.00002035586,0.00106982,0.00005478066,0.00148152,0.974109,0.0002741173,0.004896752,0.0000119624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968555,0.0006713115,0.0004782939,0.00006357583,0.00003825462,0.00001219842,0.0003930425,0.00005344725,0.001434308],"genre_scores_gemma":[0.9956956,0.0005622126,0.0004534107,0.00006344901,0.000006149774,0.00001780939,0.0006487705,0.0000122945,0.002540248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002707086,"threshold_uncertainty_score":0.009056151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02308350460246396,"score_gpt":0.2855101024871811,"score_spread":0.2624265978847172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}