{"id":"W4212891972","doi":"10.26508/lsa.202101103","title":"Human immunodeficiency virus type 1 impairs sumoylation","year":2022,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"York University; Gilead Sciences; European Molecular Biology Organization","keywords":"SUMO protein; Biology; Immune system; Intrinsic immunity; Viral replication; Jurkat cells; Cell biology; Virology; SAMHD1; Virus; T cell; Immunity; Immunology; Ubiquitin; Genetics; Gene; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006120512,0.00009288191,0.00007139587,0.0000351961,0.0008967771,0.0000443256,0.000603979,0.00002736335,0.0002382325],"category_scores_gemma":[0.0001061628,0.00009748963,0.00003788536,0.0005243893,0.00024605,0.00001189482,0.000317243,0.0001117514,0.00004377855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000336996,"about_ca_system_score_gemma":0.0002850899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003033588,"about_ca_topic_score_gemma":0.000005482249,"domain_scores_codex":[0.9987596,0.0000438563,0.0001445941,0.0003934488,0.0003467228,0.0003117874],"domain_scores_gemma":[0.9993803,0.000003147498,0.00007947379,0.0003756725,0.00007570278,0.00008572778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001363238,0.00003673288,0.001386668,0.000002999166,0.000002223704,0.000001022139,0.00007948051,0.0004395574,0.996164,0.0006760946,0.0007248024,0.0004727681],"study_design_scores_gemma":[0.000462084,0.001129688,0.02244356,0.000008434135,0.000007088077,0.0000218667,0.0004342772,0.0006676551,0.8429249,0.0005933507,0.1307831,0.0005239936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927348,0.001036939,0.000089294,0.0001352357,0.0003489317,0.0001556263,0.00001560771,0.00002359607,0.005459956],"genre_scores_gemma":[0.9977206,0.00003747548,0.0002648376,0.0006407824,0.00008915303,0.00003491541,0.00002511954,0.00000967092,0.001177464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1532391,"threshold_uncertainty_score":0.6897376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02308350460246396,"score_gpt":0.2855101024871811,"score_spread":0.2624265978847172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}