{"id":"W4212895035","doi":"10.21203/rs.3.rs-1380362/v1","title":"The iSEARCH Trials of oral Sildenafil in labour: Protocol for a randomised trial in 3,200 Australian women and Rationale for an Individual Participant Data Prospective Meta-Analysis of trials in 14,000 women in high-income countries and a mega-trial of 50,000 women in low or middle-income countries.","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Sydney Medical School; National Health and Medical Research Council; Royal College of Surgeons in Ireland; University of Toronto; University of Melbourne; Feinberg School of Medicine; University of New South Wales; Faculty of Medicine and Health, University of Sydney; James Cook University; Imperial College London; Egerton University; Murdoch Children's Research Institute; Children’s Hospital of Wisconsin Research Institute; McMaster University; Johns Hopkins University; Northwestern University","keywords":"Medicine; Sildenafil; Placebo; Randomized controlled trial; Relative risk; Clinical endpoint; Adverse effect; Meta-analysis; Obstetrics; Fetal distress; Distress; Pediatrics; Pregnancy; Confidence interval; Surgery; Internal medicine; Fetus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.09430626,0.006790411,0.01237669,0.003065866,0.002683298,0.006103943,0.003363772,0.009579876,0.03811066],"category_scores_gemma":[0.1197574,0.00414413,0.01678826,0.003503492,0.004376193,0.004945955,0.003040851,0.01118671,0.01118684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005185244,"about_ca_system_score_gemma":0.01117222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002351664,"about_ca_topic_score_gemma":0.004365651,"domain_scores_codex":[0.9226528,0.05639318,0.01023949,0.003751261,0.004607473,0.002355796],"domain_scores_gemma":[0.9710773,0.01082138,0.00661868,0.004259657,0.004941769,0.002281246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.6798413,0.002187311,0.002527773,0.1562827,0.02362404,0.0007542144,0.00121673,0.003530958,0.004574175,0.01367391,0.06464743,0.0471394],"study_design_scores_gemma":[0.8179054,0.01196919,0.006492007,0.02799434,0.0150841,0.0003018987,0.0002988355,0.004026637,0.002248706,0.01436056,0.09888619,0.0004320719],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.001800728,0.002582748,0.003521829,0.00141245,0.001461869,0.9845062,0.002983679,0.0001736278,0.001556852],"genre_scores_gemma":[0.002774167,0.0004593991,0.003763937,0.0007701147,0.0001040384,0.9910454,0.0004342633,0.00002253,0.0006260738],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.09430626,"threshold_uncertainty_score":0.4987451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4447568787359346,"score_gpt":0.5108228946779314,"score_spread":0.06606601594199679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}