{"id":"W4212895132","doi":"10.3390/metabo12020172","title":"Native Microbiome Members of C. elegans Act Synergistically in Biosynthesis of Pyridoxal 5′-Phosphate","year":2022,"lang":"en","type":"article","venue":"Metabolites","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Christian-Albrechts-Universität zu Kiel; Canada Research Chairs","keywords":"Biology; Microbiome; Caenorhabditis elegans; Microbiology; Axenic; Host (biology); In vivo; Pyridoxal; Biochemistry; Biosynthesis; Nematode; Bacteria; Genetics; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003889791,0.0001632186,0.0003322758,0.0001388289,0.00005030285,0.000006871908,0.0003375735,0.00006868415,0.0001954884],"category_scores_gemma":[0.0001752794,0.0001678241,0.0001293997,0.0002496007,0.0001845488,0.000003373922,0.0002301265,0.0001045922,0.000001400825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001561477,"about_ca_system_score_gemma":0.0000960061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000201638,"about_ca_topic_score_gemma":0.00004671418,"domain_scores_codex":[0.9987042,0.0001526905,0.0003864673,0.0003089706,0.0001941119,0.0002535543],"domain_scores_gemma":[0.9993094,0.00004414399,0.0001729545,0.0003279602,0.0000952747,0.00005023288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007323334,0.0001990316,0.005271681,0.00004009169,0.00009629747,0.000002669587,0.0005391586,0.0009551619,0.9916736,0.0005431052,0.0001269226,0.0004790459],"study_design_scores_gemma":[0.0003746316,0.0001540061,0.00729662,0.000006190218,0.00005329115,0.000004337634,0.0002918243,0.0001094048,0.9798474,0.0001569362,0.01152876,0.0001765627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957188,0.002854499,0.0003383538,0.00009212684,0.0001598304,0.0001461339,0.0002236866,0.000006371764,0.0004601993],"genre_scores_gemma":[0.9974363,0.0002176178,0.001823407,0.00009855439,0.00003767928,0.000017434,0.00006615774,0.00002546463,0.0002773643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01182616,"threshold_uncertainty_score":0.684367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007039512028218137,"score_gpt":0.2229282153848089,"score_spread":0.2158887033565907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}