{"id":"W4212895132","doi":"10.3390/metabo12020172","title":"Native Microbiome Members of C. elegans Act Synergistically in Biosynthesis of Pyridoxal 5′-Phosphate","year":2022,"lang":"en","type":"article","venue":"Metabolites","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Christian-Albrechts-Universität zu Kiel; Canada Research Chairs","keywords":"Biology; Microbiome; Caenorhabditis elegans; Microbiology; Axenic; Host (biology); In vivo; Pyridoxal; Biochemistry; Biosynthesis; Nematode; Bacteria; Genetics; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001540722,0.0005957905,0.0004043481,0.0004090516,0.0003819857,0.0004574214,0.000212518,0.0003324274,0.0006957726],"category_scores_gemma":[0.0001829382,0.0002690735,0.0003553001,0.0002067765,0.0002265985,0.0003608851,0.0006113473,0.0003728284,0.0002451212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002197949,"about_ca_system_score_gemma":0.0003135244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001102121,"about_ca_topic_score_gemma":0.002425808,"domain_scores_codex":[0.9997314,0.00002213249,0.00001867251,0.00008962071,0.0000904844,0.00004767261],"domain_scores_gemma":[0.9998259,0.00002081959,0.00005910223,0.00001670572,0.00003248882,0.00004495973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006618931,0.00001197555,0.001126988,0.00005192866,0.000006873964,0.0000610018,0.00001346895,0.00002072252,0.9974132,0.00001591358,0.000016598,0.001195108],"study_design_scores_gemma":[0.00001112311,0.0004477377,0.07360172,0.00002493168,0.00004780421,0.0006344396,0.0001413683,0.0008594309,0.9205528,0.00007931997,0.003573196,0.00002610322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925144,0.001992591,0.002620022,0.0001024518,0.00002756507,0.00005274854,0.0009679498,0.0001053784,0.001616843],"genre_scores_gemma":[0.9887215,0.001176927,0.007101374,0.00007930518,0.000008763674,0.00006208302,0.0008612636,0.00001761794,0.001971234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001102121,"threshold_uncertainty_score":0.002327561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007039512028218137,"score_gpt":0.2229282153848089,"score_spread":0.2158887033565907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}