{"id":"W4212895767","doi":"10.1200/jco.2022.40.6_suppl.tps285","title":"PROTEUS: A randomized, double-blind, placebo (PBO)-controlled, phase 3 trial of apalutamide (APA) plus androgen deprivation therapy (ADT) versus PBO plus ADT prior to radical prostatectomy (RP) in patients (pts) with localized or locally advanced high-risk prostate cancer (PC).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Janssen Research and Development","keywords":"Medicine; Androgen deprivation therapy; Prostate cancer; Urology; Prostatectomy; Clinical endpoint; Perioperative; Lymph node; Internal medicine; Nuclear medicine; Oncology; Cancer; Surgery; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001280591,0.002213213,0.002805196,0.0006477312,0.0005992331,0.001236944,0.001126825,0.001850636,0.007566864],"category_scores_gemma":[0.001325822,0.0007682424,0.001706741,0.0004690183,0.00140916,0.001079472,0.0005574716,0.002958375,0.001279297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007194318,"about_ca_system_score_gemma":0.001574636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001028262,"about_ca_topic_score_gemma":0.002633601,"domain_scores_codex":[0.9995444,0.0002341817,0.00002115752,0.00009055846,0.00003332168,0.00007618548],"domain_scores_gemma":[0.999332,0.0001365867,0.0001773894,0.00005164509,0.0000438007,0.0002585527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9842849,0.007117719,0.0002052521,0.0003924926,0.0003471674,0.00001703047,0.00002732991,0.0001307587,0.001766819,0.00008140886,0.0004940752,0.005135078],"study_design_scores_gemma":[0.9625845,0.03601472,0.0004916435,0.0000178657,0.0001404776,0.00001420992,0.00001240662,0.0001635064,0.0001703211,0.0001092461,0.0002736494,0.000007610322],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775862,0.003692867,0.001015871,0.0009917405,0.001111379,0.01055383,0.001942543,0.0003904501,0.002715098],"genre_scores_gemma":[0.9713567,0.002295789,0.002653001,0.001655575,0.0005955031,0.01536425,0.001292027,0.00005369832,0.00473333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007566864,"threshold_uncertainty_score":0.02531368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08082467148519223,"score_gpt":0.4503510215185925,"score_spread":0.3695263500334002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}