{"id":"W4212905493","doi":"10.1128/spectrum.00681-21","title":"Real-Time RT-PCR Allelic Discrimination Assay for Detection of N501Y Mutation in the Spike Protein of SARS-CoV-2 Associated with B.1.1.7 Variant of Concern","year":2022,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Sinai Health System; Hospital for Sick Children; Public Health Ontario; University of Toronto","funders":"Public Health Ontario","keywords":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Pandemic; Spike Protein; Coronavirus disease 2019 (COVID-19); Coronavirus; Virology; Biology; 2019-20 coronavirus outbreak; Allele; Spike (software development); Mutation; Genetics; Gene; Disease; Medicine; Infectious disease (medical specialty); Computer science; Outbreak","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001355847,0.0001296776,0.0003979571,0.0002613005,0.00007052775,0.000003619624,0.0001788655,0.0001125377,0.0000119341],"category_scores_gemma":[0.0002484556,0.00009569428,0.00009189625,0.0004626021,0.0002058737,0.00003716345,0.00005030932,0.0002322712,0.000001615036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002298716,"about_ca_system_score_gemma":0.0002196197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001254346,"about_ca_topic_score_gemma":0.001014647,"domain_scores_codex":[0.9984374,0.0004513222,0.0004336828,0.0002572216,0.0001641054,0.0002562463],"domain_scores_gemma":[0.99898,0.0002556747,0.0003809695,0.0002376941,0.0001393902,0.000006290702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001177662,0.0004005822,0.001223941,0.00009794591,0.0001067501,0.00001591035,0.001059525,0.000004448323,0.9952142,0.0003092536,0.00004279961,0.0003470448],"study_design_scores_gemma":[0.002714583,0.003249377,0.006228636,0.00006221346,0.00007913713,0.00007706361,0.000519168,0.0005214239,0.9855381,0.0004585193,0.0004588613,0.00009288558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965287,0.00004482415,0.0006493519,0.0006808088,0.00003835713,0.001628751,0.0001062415,0.00001745192,0.0003054433],"genre_scores_gemma":[0.9989714,0.000001159811,0.0001017439,0.0005193811,0.00002127939,0.0002159373,0.0001201537,0.00001901429,0.0000299548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009676006,"threshold_uncertainty_score":0.39023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03436884665884776,"score_gpt":0.3119502303615705,"score_spread":0.2775813837027228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}