{"id":"W4212906205","doi":"10.1097/fpc.0000000000000466","title":"Accuracy and applications of sequencing and genotyping approaches for CYP2A6 and homologous genes","year":2022,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Cancer Institute; National Institute on Drug Abuse; Canadian Institutes of Health Research","keywords":"Genotyping; Gene; SNP genotyping; DNA sequencing; Chromosome; Homologous chromosome; SNP; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05732942,0.00108048,0.0009370003,0.00179646,0.0005528065,0.002110695,0.001693528,0.001824983,0.0009540546],"category_scores_gemma":[0.08662928,0.0006555567,0.001196209,0.001385164,0.001417183,0.001041025,0.001644907,0.001324498,0.0006389222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009024935,"about_ca_system_score_gemma":0.0007113144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003392449,"about_ca_topic_score_gemma":0.004621549,"domain_scores_codex":[0.9123187,0.05782203,0.003341801,0.01248711,0.01295104,0.001079288],"domain_scores_gemma":[0.8872191,0.07774791,0.01064322,0.01473223,0.009070984,0.0005864794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001337202,0.0001009527,0.7798593,0.0005463542,0.002899035,0.0001722381,0.001291785,0.0142988,0.03334631,0.002011104,0.0008097015,0.1633272],"study_design_scores_gemma":[0.0001289814,0.001281138,0.8459053,0.0003449422,0.002129618,0.002314518,0.0004441522,0.07706937,0.05472402,0.005500621,0.01000435,0.0001528736],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7714924,0.01737642,0.2008962,0.001389114,0.0002974782,0.0002187841,0.001471297,0.0004482203,0.006410092],"genre_scores_gemma":[0.9424163,0.001077228,0.05375316,0.0004217273,0.0001081716,0.0001134914,0.0007956533,0.0001198631,0.001194385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05732942,"threshold_uncertainty_score":0.3031906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1599865546918643,"score_gpt":0.3937307608366337,"score_spread":0.2337442061447694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}