{"id":"W4212929726","doi":"10.1039/d1ra08443g","title":"Solvent-free synthesis of 3,5-isoxazoles <i>via</i> 1,3-dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over Cu/Al<sub>2</sub>O<sub>3</sub> surface under ball-milling conditions","year":2022,"lang":"en","type":"article","venue":"RSC Advances","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre in Green Chemistry and Catalysis; Concordia University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Centre in Green Chemistry and Catalysis","keywords":"Terminal (telecommunication); Cycloaddition; Solvent; Chemistry; 1,3-Dipolar cycloaddition; Dipole; Combinatorial chemistry; Computational chemistry; Organic chemistry; Catalysis; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001651673,0.0003426094,0.0004779979,0.00006364172,0.0005514802,0.00002824874,0.0004329838,0.0001143717,0.0002277898],"category_scores_gemma":[0.0001139045,0.0003900962,0.0002029589,0.0002846678,0.0004262359,0.0003603714,0.0002884418,0.0003290287,0.00000407997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008845879,"about_ca_system_score_gemma":0.00006723275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001919093,"about_ca_topic_score_gemma":0.00003807058,"domain_scores_codex":[0.9979058,0.00002922418,0.0006490441,0.0005655906,0.0004820799,0.0003682874],"domain_scores_gemma":[0.9978139,0.0007329355,0.0005733353,0.0006531799,0.00009661107,0.0001299849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005650954,0.000294916,0.0007397328,0.0003963886,0.00009804763,0.000006049052,0.0000864835,0.003279487,0.9920812,0.0003051844,0.000530198,0.002125826],"study_design_scores_gemma":[0.0004648646,0.00002882762,0.0003275467,0.0002030089,0.0001679644,0.00004820742,0.0008929143,0.000694004,0.9895966,0.004585706,0.002600953,0.0003893784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933688,0.002324966,0.0002495373,0.0002957432,0.00006758676,0.000144913,0.002841813,0.0000963471,0.0006102599],"genre_scores_gemma":[0.9967928,0.00215058,0.0001874658,0.00008405135,0.0001227857,0.0001990007,0.0003941403,0.00004636231,0.00002281754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004280522,"threshold_uncertainty_score":0.9998551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008274566305308973,"score_gpt":0.2351052724416116,"score_spread":0.2268307061363026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}