{"id":"W4212931256","doi":"10.3410/f.738664573.793585211","title":"Faculty Opinions recommendation of The phosphoinositide 3-kinase inhibitor alpelisib restores actin organization and improves proximal tubule dysfunction in vitro and in a mouse model of Lowe syndrome and Dent disease.","year":2021,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Cystinosis Research Foundation; Cancer Research UK; University of California, San Francisco; Institute of Genetics; National Institutes of Health; Isaac Newton Trust; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Lowe Syndrome Trust; Invitae; National Science Foundation; Wellcome Trust; Universität Zürich","keywords":"In vitro; Proximal tubule; Kinase; Disease; Medicine; Internal medicine; Pharmacology; Chemistry; Cell biology; Endocrinology; Biology; Biochemistry; Kidney","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001381451,0.001583645,0.001611588,0.00234943,0.0007126694,0.002166011,0.002204966,0.002022774,0.0673011],"category_scores_gemma":[0.009222175,0.0004789278,0.001998088,0.002993545,0.0002428676,0.001078951,0.001529595,0.001425885,0.04493909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001238852,"about_ca_system_score_gemma":0.002492041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01507906,"about_ca_topic_score_gemma":0.04319423,"domain_scores_codex":[0.9989377,0.0002288681,0.0001311459,0.0002940373,0.0002802893,0.0001280011],"domain_scores_gemma":[0.9969935,0.001240045,0.0003723082,0.0003618303,0.0006724897,0.0003597213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003004823,0.00003853178,0.002804927,0.003459277,0.0002432292,0.00004578005,0.00002111484,0.0003618484,0.0003087492,0.0003377214,0.985369,0.006709281],"study_design_scores_gemma":[0.001187428,0.00007395892,0.01556948,0.001434645,0.000425353,0.0001507426,0.00006618226,0.0006638278,0.0008554128,0.001221625,0.9782972,0.00005418707],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.0003308538,0.0004506773,0.00005613923,0.0002057916,0.00004302829,0.00001648703,0.9978063,0.0001805358,0.0009102438],"genre_scores_gemma":[0.001250931,0.0003123004,0.0003248451,0.0001475427,0.00001560583,0.0001001635,0.9964401,0.00005133015,0.001357067],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.0673011,"threshold_uncertainty_score":0.2251446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01115870003988171,"score_gpt":0.2630955937062998,"score_spread":0.251936893666418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}