{"id":"W4212931835","doi":"10.1016/j.molcel.2022.02.011","title":"Regulation of GTPase function by autophosphorylation","year":2022,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Institute of General Medical Sciences; Office of Science; Canada Foundation for Innovation; Argonne National Laboratory; Princess Margaret Cancer Foundation; Cancer Research UK; American Cancer Society; Doris Duke Charitable Foundation; Office of Research Infrastructure Programs, National Institutes of Health; Taiho Pharmaceutical; National Institutes of Health; Canadian Cancer Society Research Institute; National Cancer Institute; National Science Foundation","keywords":"Biology; Autophosphorylation; GTPase; Cell biology; Function (biology); Computational biology; Phosphorylation; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002620341,0.0004881793,0.0002179686,0.0004254324,0.0003143762,0.0009115613,0.0004367778,0.0003081726,0.001975754],"category_scores_gemma":[0.0002375603,0.0002255557,0.0002632278,0.0002120685,0.0003969205,0.0006617776,0.0004907795,0.0009043481,0.0005796841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005416101,"about_ca_system_score_gemma":0.0001726361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002979718,"about_ca_topic_score_gemma":0.0004623852,"domain_scores_codex":[0.9998592,0.00002478117,0.000009908162,0.00003821579,0.00003173007,0.00003618539],"domain_scores_gemma":[0.9998417,0.0000416815,0.0000246905,0.00004535024,0.00001349287,0.00003313569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002212829,0.00005448336,0.0002857083,0.00003290812,0.000005785292,0.0001534812,0.00002348144,0.0002225674,0.9904543,0.004135396,0.0001076176,0.004303079],"study_design_scores_gemma":[0.00002675601,0.00008520723,0.004374438,0.000007224527,0.000008567997,0.0005824796,0.00003202904,0.003972041,0.9863404,0.002012287,0.002547427,0.00001109251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9734567,0.005728012,0.01034181,0.000583852,0.0001375126,0.00002105516,0.0002041364,0.0003822261,0.009144722],"genre_scores_gemma":[0.994989,0.001003091,0.001385508,0.00005405555,0.00002545701,0.00000931727,0.0001406335,0.00004048775,0.002352363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001975754,"threshold_uncertainty_score":0.006609499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003956826516128015,"score_gpt":0.1919221939538253,"score_spread":0.1879653674376973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}