{"id":"W4212935676","doi":"10.1101/2022.02.11.22270859","title":"Clinical and economic benefits of lenzilumab plus standard of care compared with standard of care alone for the treatment of hospitalized patients with Coronavirus Disease 19 (COVID-19) from the perspective of National Health Service England","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"EVERSANA (Canada)","funders":"","keywords":"Medicine; Cohort; Mechanical ventilation; Population; Intensive care unit; Emergency medicine; Clinical trial; Cohort study; Health care; Intensive care medicine; Internal medicine; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003766084,0.0008119715,0.00127881,0.001317547,0.0001613014,0.001528079,0.0006034499,0.000774334,0.003367267],"category_scores_gemma":[0.01491541,0.000361569,0.003258244,0.001327374,0.0003477308,0.0009841269,0.001101193,0.001001762,0.0001893832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004560296,"about_ca_system_score_gemma":0.002390951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01304064,"about_ca_topic_score_gemma":0.01109502,"domain_scores_codex":[0.9954764,0.003243115,0.0002600288,0.0002437737,0.0004948958,0.0002818489],"domain_scores_gemma":[0.9957392,0.002458772,0.001019378,0.0001044605,0.0003449243,0.0003331946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.09048489,0.0019993,0.2061567,0.01255818,0.02680195,0.001130336,0.000398934,0.2861919,0.002142618,0.01479282,0.02078217,0.3365603],"study_design_scores_gemma":[0.03727353,0.04691358,0.4301485,0.008632349,0.03478216,0.002354063,0.001617593,0.3846632,0.004519811,0.01711959,0.03152901,0.0004465288],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9251511,0.03791261,0.005513994,0.004538835,0.0004178824,0.00144719,0.01127718,0.0001170641,0.01362429],"genre_scores_gemma":[0.990864,0.003401539,0.002578299,0.000337612,0.00004266511,0.0002870634,0.001818327,0.00000984141,0.0006606303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01304064,"threshold_uncertainty_score":0.03308737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1019454871864891,"score_gpt":0.4474296346798257,"score_spread":0.3454841474933366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}