{"id":"W4212942043","doi":"10.3390/biology11020316","title":"Multielectrode Arrays for Functional Phenotyping of Neurons from Induced Pluripotent Stem Cell Models of Neurodevelopmental Disorders","year":2022,"lang":"en","type":"review","venue":"Biology","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Hospital for Sick Children; University of Toronto","funders":"Simons Foundation; Autism Speaks","keywords":"Induced pluripotent stem cell; Biology; Context (archaeology); Neuroscience; Computational biology; Data science; Computer science; Embryonic stem cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008148353,0.0003514705,0.0009395031,0.0002417765,0.0001269137,0.000006656852,0.0005611001,0.0001365827,0.00002718692],"category_scores_gemma":[0.00008183541,0.0003152465,0.0003669438,0.0003724324,0.0001237263,0.00008990194,0.0002344096,0.0003756948,0.000001705939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005314688,"about_ca_system_score_gemma":0.0002052815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000214105,"about_ca_topic_score_gemma":0.000001982158,"domain_scores_codex":[0.9977447,0.0001985495,0.0006567992,0.0008216524,0.0001781215,0.0004002137],"domain_scores_gemma":[0.9982651,0.0008974157,0.0004739684,0.0002902005,0.00001256806,0.00006071704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000482016,0.0001882677,0.000002104156,0.001696297,0.00001755895,0.000002516398,0.00008927997,0.001338667,0.5411182,0.0008494697,0.00002650755,0.4546229],"study_design_scores_gemma":[0.001260163,0.00119486,0.00001021192,0.000548967,0.0003362365,0.00003469846,0.00007466105,0.02037856,0.1175642,0.0006500366,0.8565155,0.001431902],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04837314,0.9074096,0.02449345,0.00006665,0.01070909,0.005492695,0.002590016,0.0003118285,0.00055353],"genre_scores_gemma":[0.04220514,0.9570264,0.0001190984,0.0001069251,0.00006921613,0.0002706391,0.00007842767,0.00007304028,0.00005106522],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.856489,"threshold_uncertainty_score":0.99993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1579959097977464,"score_gpt":0.2971293035771709,"score_spread":0.1391333937794245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}