{"id":"W4212945886","doi":"10.17925/usn.2021.17.2.70","title":"Innovative Therapeutic Development Programme for the Treatment of Early Alzheimer's Disease: Lecanemab (BAN2401)","year":2021,"lang":"en","type":"article","venue":"touchREVIEWS in Neurology","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada)","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute on Aging","keywords":"Disease; Alzheimer's disease; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009903876,0.0004741349,0.0002683428,0.0004877429,0.0003648413,0.0008040603,0.0005952601,0.0009776405,0.01561483],"category_scores_gemma":[0.0004447355,0.0000820096,0.0003988405,0.0002581683,0.0002843094,0.0004884378,0.0007200228,0.00121711,0.005046013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008380053,"about_ca_system_score_gemma":0.001621675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00124053,"about_ca_topic_score_gemma":0.002340688,"domain_scores_codex":[0.9997754,0.00005252452,0.00001177903,0.0000303764,0.00006552909,0.00006441375],"domain_scores_gemma":[0.9997361,0.00002938789,0.0000326142,0.00001070101,0.00005815808,0.0001329733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001434302,0.0007674256,0.0008214264,0.0008910613,0.00006798725,0.0005927373,0.00006958227,0.0002414374,0.03116534,0.006858561,0.1480519,0.8090383],"study_design_scores_gemma":[0.001568756,0.003601541,0.005210083,0.0004029299,0.0001434381,0.00173591,0.00004854055,0.0004771016,0.03437657,0.002199253,0.9502023,0.00003358598],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1119707,0.4237529,0.01646782,0.1066037,0.01949528,0.00217107,0.005878369,0.002312174,0.3113481],"genre_scores_gemma":[0.3077289,0.2752835,0.02814161,0.03989932,0.008035456,0.001580706,0.008303029,0.0003639339,0.3306636],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01561483,"threshold_uncertainty_score":0.05223686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1204789983611148,"score_gpt":0.3635085386470207,"score_spread":0.2430295402859059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}