{"id":"W4212946754","doi":"10.1186/s12987-022-00313-3","title":"Acquired hydrocephalus is associated with neuroinflammation, progenitor loss, and cellular changes in the subventricular zone and periventricular white matter","year":2022,"lang":"en","type":"article","venue":"Fluids and Barriers of the CNS","topic":"Cerebrospinal fluid and hydrocephalus","field":"Neuroscience","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health","keywords":"Subventricular zone; Neuroinflammation; Gliosis; Hydrocephalus; White matter; Lateral ventricles; Pathology; Microglia; Neuropathology; Medicine; Ventriculomegaly; Astrocytosis; Cerebrospinal fluid; Oligodendrocyte; Neural stem cell; Biology; Internal medicine; Inflammation; Central nervous system; Stem cell; Myelin; Cell biology; Immunohistochemistry; Surgery; Magnetic resonance imaging; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000316323,0.0001827201,0.0002222335,0.00008596418,0.0006060268,0.00007857598,0.0002905562,0.0000420009,0.0001662072],"category_scores_gemma":[0.00008672756,0.0001115564,0.00004649597,0.0005091184,0.0003110453,0.0001032522,0.0002699194,0.0001471875,8.984788e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002819736,"about_ca_system_score_gemma":0.00003020035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002272455,"about_ca_topic_score_gemma":0.00001132378,"domain_scores_codex":[0.9984314,0.0002780292,0.0001962062,0.0003639318,0.0004577875,0.0002726341],"domain_scores_gemma":[0.9994695,0.00006236439,0.000112079,0.0002432977,0.00002762853,0.000085179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003104845,0.000219211,0.39162,0.0001536344,0.0000678867,0.0004188269,0.0135993,0.00007564034,0.5899829,0.0005438785,0.002600758,0.000407501],"study_design_scores_gemma":[0.007863593,0.002348488,0.3665245,0.0002440847,0.0006040904,0.001962631,0.005069164,0.01293466,0.590562,0.0009793399,0.009429654,0.00147776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937454,0.001029882,0.00001080374,0.004499442,0.00007239343,0.0005172545,0.00006273231,0.00001324282,0.00004882944],"genre_scores_gemma":[0.998409,0.00009237064,0.000006015905,0.001127538,0.00003194752,0.00004680771,0.000004189003,0.00001819427,0.0002639491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02509545,"threshold_uncertainty_score":0.466113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007150627835393412,"score_gpt":0.1930761491130907,"score_spread":0.1859255212776973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}