{"id":"W4212956662","doi":"10.1128/mbio.03718-21","title":"Inhibition of Protein <i>N-</i> Glycosylation Blocks SARS-CoV-2 Infection","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"National Institute on Minority Health and Health Disparities; Economic and Social Research Council; Biotechnology and Biological Sciences Research Council; University of Texas at El Paso; National Institutes of Health; University of Oxford; National Institute of Allergy and Infectious Diseases; Medical Research Council; Royal Society; National Institute for Health and Care Research; National Institute for Health Research Health Protection Research Unit; Public Health England; Liverpool School of Tropical Medicine; Engineering and Physical Sciences Research Council; UK Research and Innovation; Wellcome Trust","keywords":"Virology; Glycosylation; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Biology; Sars virus; Microbiology; Computational biology; Medicine; Infectious disease (medical specialty); Disease; Outbreak; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001365657,0.00006732764,0.0000690286,0.00003732907,0.00009572206,0.000008546784,0.00004624117,0.00004236846,0.00001855066],"category_scores_gemma":[0.00001326702,0.00007040409,0.00005425301,0.00009678771,0.00001216501,0.000004868828,0.0001116044,0.00006456614,0.000002471532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001467197,"about_ca_system_score_gemma":0.0000210474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007338078,"about_ca_topic_score_gemma":0.00001212536,"domain_scores_codex":[0.9995111,0.00002581613,0.0001808242,0.00009948832,0.00009427941,0.00008847413],"domain_scores_gemma":[0.9996867,0.000001212648,0.0001134712,0.0001587125,0.00003158201,0.000008364851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004798921,0.00006158327,0.0006695141,0.0000192234,0.00001280373,1.393016e-7,0.00005550684,0.0001004001,0.9966177,0.0001027812,0.0007973529,0.001515014],"study_design_scores_gemma":[0.0003653636,0.0003577842,0.0006591945,0.000004583709,0.000006605002,0.000008347874,0.00002927362,0.0003852369,0.9687003,0.0001637535,0.02923284,0.00008672837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961375,0.00008916065,0.0008914567,0.00004870461,0.00006410267,0.0002201419,0.00001407286,0.000009224732,0.002525663],"genre_scores_gemma":[0.9991837,0.00001100203,0.0002127357,0.00008380389,0.00004121532,0.0000606793,0.000260125,0.000008474695,0.0001383338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02843549,"threshold_uncertainty_score":0.2870996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01396677988835081,"score_gpt":0.2293579340040495,"score_spread":0.2153911541156987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}