{"id":"W4212956662","doi":"10.1128/mbio.03718-21","title":"Inhibition of Protein <i>N-</i> Glycosylation Blocks SARS-CoV-2 Infection","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"National Institute on Minority Health and Health Disparities; Economic and Social Research Council; Biotechnology and Biological Sciences Research Council; University of Texas at El Paso; National Institutes of Health; University of Oxford; National Institute of Allergy and Infectious Diseases; Medical Research Council; Royal Society; National Institute for Health and Care Research; National Institute for Health Research Health Protection Research Unit; Public Health England; Liverpool School of Tropical Medicine; Engineering and Physical Sciences Research Council; UK Research and Innovation; Wellcome Trust","keywords":"Virology; Glycosylation; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Biology; Sars virus; Microbiology; Computational biology; Medicine; Infectious disease (medical specialty); Disease; Outbreak; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001102602,0.0002443236,0.0002002466,0.00009322377,0.0001002396,0.0001998714,0.0001831759,0.0001689136,0.001917567],"category_scores_gemma":[0.0001302256,0.00006845014,0.0001576541,0.00007543565,0.0001821641,0.0001272233,0.0001259758,0.0005250731,0.0005576682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001773252,"about_ca_system_score_gemma":0.0002424644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007381418,"about_ca_topic_score_gemma":0.001732099,"domain_scores_codex":[0.999916,0.00001649933,0.000004571223,0.00001170417,0.00002007601,0.00003125476],"domain_scores_gemma":[0.999949,0.000005714011,0.00001522551,0.000006441477,0.000005338095,0.00001829115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004541461,0.0001780682,0.0001708356,0.00004640417,0.00001102684,0.00002098041,0.000008947074,0.0002812619,0.9920303,0.0003116167,0.0005803761,0.005906088],"study_design_scores_gemma":[0.00008649191,0.002402814,0.005231169,0.0000219153,0.00002361711,0.000177188,0.00003197769,0.001998327,0.9757881,0.0001887378,0.01404103,0.00000860242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827127,0.002872419,0.003582626,0.0005016128,0.0001410046,0.00004428739,0.0004015059,0.0002935044,0.009450208],"genre_scores_gemma":[0.992624,0.001499193,0.00178167,0.0001857196,0.00002443657,0.00002116312,0.0004417374,0.00004297195,0.003379059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001917567,"threshold_uncertainty_score":0.00641489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01396677988835081,"score_gpt":0.2293579340040495,"score_spread":0.2153911541156987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}