{"id":"W4212958917","doi":"10.1101/2022.02.06.479326","title":"A transcytotic actin shift polarizes vesicle trajectories and partitions apicobasal epithelial membrane domains","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; School of Medicine, Emory University; National Institutes of Health; Boston Area Diabetes Endocrinology Research Center; McGill University; University of Rochester; Medical Center, University of Rochester; Emory University; University of California, San Diego; Massachusetts General Hospital","keywords":"Polarity (international relations); Cell polarity; Vesicle; Epithelial polarity; Membrane; Actin; Directionality; Apical membrane; Cell biology; Cytoplasm; Biology; Biophysics; Biochemistry; Cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005151231,0.0001809962,0.0001198804,0.0001658205,0.0001685023,0.0002695488,0.0001415815,0.0002083973,0.001301064],"category_scores_gemma":[0.00006747806,0.0001137771,0.00009831507,0.00006623588,0.0002054098,0.0001267785,0.0002097625,0.0003282987,0.0003094622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003698716,"about_ca_system_score_gemma":0.0001573567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001053012,"about_ca_topic_score_gemma":0.001263765,"domain_scores_codex":[0.9999567,0.000003337718,0.000001346129,0.00001387745,0.00001278438,0.00001201909],"domain_scores_gemma":[0.9999361,0.000007194288,0.00001499935,0.000009816718,0.00001196337,0.00001996187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000336828,0.000006302701,0.0002678566,0.000005430574,0.000001120693,0.00003855964,0.000005118457,0.0001225062,0.9984647,0.0001955072,0.00004638524,0.0008128959],"study_design_scores_gemma":[0.00001367624,0.00006589373,0.01706714,0.000006367685,0.000005505924,0.0001994349,0.00004461838,0.006751447,0.9740108,0.0002159637,0.001611525,0.000007627934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953087,0.0001471175,0.002806462,0.00005567118,0.0000215095,0.000006727606,0.0001275612,0.00007726959,0.001449073],"genre_scores_gemma":[0.9963362,0.0001000745,0.001074354,0.00001867132,0.000004391113,0.000006854176,0.00008092009,0.00002295766,0.00235545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001301064,"threshold_uncertainty_score":0.00435245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009968027617126948,"score_gpt":0.2131505271372003,"score_spread":0.2031824995200733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}