{"id":"W4212984292","doi":"10.1200/jco.2022.40.6_suppl.528","title":"Biomarker analysis and updated clinical follow-up from BLASST-1 (Bladder Cancer Signal Seeking Trial) of nivolumab, gemcitabine, and cisplatin in patients with muscle-invasive bladder cancer (MIBC) undergoing cystectomy.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Bristol-Myers Squibb","keywords":"Medicine; Cystectomy; Bladder cancer; Gemcitabine; Oncology; Nivolumab; Internal medicine; Biomarker; Clinical endpoint; Cisplatin; Cancer; Urology; Clinical trial; Chemotherapy; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001550438,0.0005083035,0.0009844744,0.0003171536,0.0003472175,0.0008180357,0.0004024787,0.0006364514,0.002170816],"category_scores_gemma":[0.001453459,0.000276279,0.0007696779,0.0004280874,0.0001995112,0.0006517308,0.0005140592,0.000922638,0.0004713413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005230355,"about_ca_system_score_gemma":0.0005084244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000753449,"about_ca_topic_score_gemma":0.00155618,"domain_scores_codex":[0.9995388,0.0001657955,0.00004390814,0.0001021421,0.00007449606,0.00007493883],"domain_scores_gemma":[0.9989769,0.0001309942,0.0004344686,0.0000670485,0.0001097961,0.0002808591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3409867,0.004122898,0.5583104,0.0008187013,0.002930732,0.0003278285,0.0002701712,0.002448508,0.009806935,0.0001640138,0.008933107,0.07088],"study_design_scores_gemma":[0.02733986,0.0644083,0.8911496,0.00008195877,0.002530745,0.0006838211,0.00009860965,0.002092762,0.00276715,0.0001913933,0.008597664,0.00005809658],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896779,0.001238982,0.0003193668,0.0001667475,0.00003786967,0.0004502941,0.006694911,0.00003613377,0.001377794],"genre_scores_gemma":[0.9771871,0.000358843,0.000575308,0.0002830471,0.0000612179,0.0006364643,0.01965205,0.000009900733,0.001235965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002170816,"threshold_uncertainty_score":0.008199573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06095202296549487,"score_gpt":0.396435263198702,"score_spread":0.3354832402332072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}