{"id":"W4212986433","doi":"10.1111/bcp.15278","title":"Acalabrutinib CYP3A‐mediated drug–drug interactions: Clinical evaluations and physiologically based pharmacokinetic modelling to inform dose adjustment strategy","year":2022,"lang":"en","type":"article","venue":"British Journal of Clinical Pharmacology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"AstraZeneca","keywords":"Physiologically based pharmacokinetic modelling; Pharmacology; Fluconazole; Pharmacokinetics; CYP3A; Drug; Chemistry; Itraconazole; Adverse effect; Therapeutic drug monitoring; Medicine; Internal medicine; Cytochrome P450; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001794209,0.0006492749,0.0008267479,0.0003409677,0.0001299924,0.001241169,0.0005245596,0.0007308011,0.001338515],"category_scores_gemma":[0.003259605,0.0003747922,0.0006763686,0.0002489632,0.000208291,0.0005280902,0.0003213517,0.0009289994,0.0004489721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008066269,"about_ca_system_score_gemma":0.001206537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002990296,"about_ca_topic_score_gemma":0.00227205,"domain_scores_codex":[0.9991562,0.0005840767,0.00003040818,0.00006114211,0.0001392965,0.00002894055],"domain_scores_gemma":[0.999194,0.0004837445,0.0001426507,0.00005448212,0.00009939845,0.00002578206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0008233645,0.0003230278,0.006963247,0.0003402879,0.0002662025,0.0002714438,0.00009490031,0.8720986,0.01923472,0.003715618,0.002504401,0.09336421],"study_design_scores_gemma":[0.00009561762,0.0005960452,0.002480507,0.00004274731,0.00007619711,0.000148618,0.00002131781,0.9882161,0.003024816,0.002011401,0.003265196,0.0000214236],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3317587,0.01060809,0.6373008,0.004310642,0.00008140619,0.0005408182,0.0008974537,0.001453258,0.01304882],"genre_scores_gemma":[0.9581077,0.001928875,0.03816787,0.0002670435,0.00003203524,0.0001981258,0.0003049852,0.0000577178,0.0009357991],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002990296,"threshold_uncertainty_score":0.009488761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1526650105576577,"score_gpt":0.5050098290107358,"score_spread":0.3523448184530781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}