{"id":"W4212989002","doi":"10.1200/jco.2022.40.6_suppl.310","title":"Predictors of objective response to first-line immuno-oncology combination therapies in metastatic renal cell carcinoma: Results from the international metastatic renal cell database consortium (IMDC).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; McMaster University; London Health Sciences Centre; Western University; Dalhousie University; University of Alberta; Queen Elizabeth II Health Sciences Centre; BC Cancer Agency; University of Calgary","funders":"Alberta Cancer Foundation","keywords":"Medicine; Nivolumab; Axitinib; Internal medicine; Ipilimumab; Renal cell carcinoma; Pembrolizumab; Oncology; Cabozantinib; Response Evaluation Criteria in Solid Tumors; Progressive disease; Expanded access; Pazopanib; Sunitinib; Cancer; Disease; Immunotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001600259,0.0001728171,0.0006267357,0.001120574,0.0002055681,0.0006831628,0.0004053152,0.000280543,0.00132236],"category_scores_gemma":[0.003613379,0.0001094785,0.0003691282,0.001891054,0.0001557508,0.0003419572,0.0005638419,0.0002734113,0.0003296134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005238818,"about_ca_system_score_gemma":0.0004830636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005490423,"about_ca_topic_score_gemma":0.008218142,"domain_scores_codex":[0.9988518,0.0003493454,0.0001898606,0.000216994,0.000303176,0.00008896263],"domain_scores_gemma":[0.9962021,0.001069794,0.001706886,0.000239529,0.0004134722,0.000368266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003865458,0.00002949735,0.9969561,0.00003558018,0.00007780771,0.00002295977,0.00002270971,0.0001125252,0.00007739475,0.000008009585,0.000387417,0.001883474],"study_design_scores_gemma":[0.000049785,0.0001214053,0.9980889,0.00001482836,0.00007561155,0.0002012781,0.00006690021,0.000642952,0.0001262699,0.000009235809,0.0005986756,0.000004126257],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987529,0.0005751348,0.00007533098,0.0000673456,0.000004631066,0.0000314438,0.01123001,0.000006254494,0.0004807322],"genre_scores_gemma":[0.9854457,0.0001585376,0.0001163369,0.00002747513,0.00001042065,0.00003231532,0.01408651,0.000003420492,0.000119078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005490423,"threshold_uncertainty_score":0.01091695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08989455035986191,"score_gpt":0.3886909595547798,"score_spread":0.2987964091949179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}