{"id":"W4213004587","doi":"10.4049/jimmunol.2100550","title":"The Purinergic Receptor P2X4 Promotes Th17 Activation and the Development of Arthritis","year":2022,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Arthritis Society; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Fondation de l’Université Laval; Université Laval","keywords":"Purinergic receptor; Cell biology; Purinergic signalling; Small interfering RNA; Receptor; T cell; Biology; Chemistry; Immunology; Cell culture; Immune system; Transfection; Biochemistry; Adenosine receptor; Extracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000158157,0.0003583868,0.000284883,0.0002612852,0.0001701699,0.0003063681,0.0001334329,0.0002787303,0.002801072],"category_scores_gemma":[0.00009683299,0.0001779354,0.0002715631,0.0001101634,0.0001971935,0.0001824964,0.0002227597,0.0007361987,0.0005827136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001495063,"about_ca_system_score_gemma":0.0001372784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002149613,"about_ca_topic_score_gemma":0.0002464694,"domain_scores_codex":[0.9998235,0.00004671108,0.00001615747,0.00002339258,0.00003927069,0.00005097694],"domain_scores_gemma":[0.999892,0.0000207189,0.00003291908,0.00001132704,0.00001146302,0.00003154664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002996812,0.00003619124,0.0003163164,0.00005809252,0.00001006948,0.0001213815,0.000009396899,0.00004221471,0.9978363,0.00006288677,0.00006517387,0.001142321],"study_design_scores_gemma":[0.00007553743,0.0009940958,0.01196239,0.00001638931,0.00004167212,0.0005524706,0.00006182508,0.001033613,0.9805459,0.0001171257,0.004592409,0.000006589225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900811,0.005399293,0.001999961,0.0001877185,0.00009042333,0.00003737337,0.0002586287,0.00006178243,0.001883698],"genre_scores_gemma":[0.9924346,0.00191899,0.001212352,0.00007050742,0.00005169957,0.00005637802,0.0001966503,0.00001293694,0.004045915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002801072,"threshold_uncertainty_score":0.009370506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006996065006516859,"score_gpt":0.2133722817387247,"score_spread":0.2063762167322078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}