{"id":"W4213010155","doi":"10.1200/jco.2022.40.6_suppl.316","title":"Association of cabozantinib dose reductions for toxicity with clinical effectiveness in metastatic renal cell carcinoma (mRCC): Results from the Canadian Kidney Cancer Information System (CKCis).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; Queen Elizabeth II Health Sciences Centre; Dalhousie University; Centre Hospitalier Universitaire de Sherbrooke; University of British Columbia; BC Cancer Agency; Hôtel-Dieu de Québec; Centre Hospitalier de l’Université de Montréal; Princess Margaret Cancer Centre; University of Calgary; McMaster University; Juravinski Cancer Centre; University of Manitoba; University Health Network; University of Alberta","funders":"","keywords":"Medicine; Sunitinib; Cabozantinib; Pazopanib; Hazard ratio; Axitinib; Renal cell carcinoma; Discontinuation; Internal medicine; Toxicity; Tyrosine-kinase inhibitor; Cohort; Cancer; Oncology; Kidney cancer; Urology; Gastroenterology; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003566272,0.0003318169,0.0006979227,0.002459755,0.0004383921,0.0008416172,0.0007565503,0.0004441929,0.002382491],"category_scores_gemma":[0.01018973,0.0001757627,0.001576271,0.006674345,0.0002287554,0.000378331,0.0006032065,0.0005937633,0.0002667079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00523789,"about_ca_system_score_gemma":0.006132166,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.6216679,"about_ca_topic_score_gemma":0.6723036,"domain_scores_codex":[0.996733,0.0004057134,0.0004449285,0.0005047703,0.001597269,0.0003142977],"domain_scores_gemma":[0.9864374,0.002883075,0.006072556,0.0006162155,0.002938086,0.00105272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001088908,0.00002525111,0.9905199,0.0001537706,0.0005125357,0.00002354702,0.0000334312,0.0003959087,0.00005897715,0.00002808893,0.002520659,0.00463906],"study_design_scores_gemma":[0.00008213522,0.00007612322,0.9977092,0.00003052082,0.0002749639,0.000039979,0.00003550235,0.0007366038,0.0000504014,0.0000135901,0.000942308,0.000008768345],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8431419,0.004960098,0.0002767768,0.0005916483,0.0000197593,0.0001324378,0.1480732,0.00005094272,0.002753218],"genre_scores_gemma":[0.9453908,0.0006992929,0.0002118452,0.0001266072,0.00002026115,0.00004640468,0.05314246,0.00001226709,0.0003500068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3783321,"threshold_uncertainty_score":0.7611204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09265056873236414,"score_gpt":0.4041913901613804,"score_spread":0.3115408214290162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}