{"id":"W4213012668","doi":"10.15252/emmm.202114552","title":"A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis","year":2022,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"H2020 European Research Council; Instituto de Salud Carlos III; Horizon 2020 Framework Programme; Universität Zürich; Centro Nacional de Investigaciones Cardiovasculares; Dipartimenti di Eccellenza; Bristol-Myers Squibb; Science Foundation Ireland; Fundació la Marató de TV3; Worldwide Cancer Research; Fundación Científica Asociación Española Contra el Cáncer; Fundación Ramón Areces; Promedica Stiftung; Comunidad de Madrid; National Cancer Institute; Ministero dell’Istruzione, dell’Università e della Ricerca; Melanoma Research Alliance; Boehringer Ingelheim Fonds; Memorial Sloan-Kettering Cancer Center; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Cancer Research Institute","keywords":"Drug; Brain metastasis; Metastasis; Drug discovery; Medicine; Drug trafficking; Computational biology; Cancer research; Biology; Bioinformatics; Pharmacology; Internal medicine; Cancer; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003077956,0.000795888,0.0005423264,0.0003926511,0.0002514866,0.0004856393,0.0004721891,0.0004895397,0.001456507],"category_scores_gemma":[0.00024138,0.0002301582,0.0004104878,0.0002134227,0.0002558917,0.000275512,0.0004505822,0.0008780546,0.0009384249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002362536,"about_ca_system_score_gemma":0.0003995011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005940243,"about_ca_topic_score_gemma":0.001631515,"domain_scores_codex":[0.9997252,0.00004417381,0.00001473037,0.00005588046,0.0001192304,0.00004083019],"domain_scores_gemma":[0.9997928,0.00005141517,0.00004634884,0.00003420647,0.00003601516,0.00003929391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003548427,0.00002313978,0.0001320047,0.00003435031,0.000007166184,0.00004226426,0.000006791215,0.0002194799,0.9975681,0.0001021192,0.0001600606,0.001669178],"study_design_scores_gemma":[0.000006785077,0.0002323845,0.001002718,0.000005861454,0.00002476743,0.0001800538,0.00001214184,0.001311301,0.9929304,0.00007627769,0.004206515,0.00001078718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6832517,0.006595889,0.2835923,0.0009345754,0.0004248424,0.001001459,0.01131464,0.002630316,0.0102543],"genre_scores_gemma":[0.8742698,0.004751534,0.105758,0.0004285082,0.00006199889,0.0007156032,0.007079222,0.0002383311,0.006697037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001456507,"threshold_uncertainty_score":0.004872501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02388341539319939,"score_gpt":0.3224262030911144,"score_spread":0.298542787697915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}