{"id":"W4213012668","doi":"10.15252/emmm.202114552","title":"A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis","year":2022,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"H2020 European Research Council; Instituto de Salud Carlos III; Horizon 2020 Framework Programme; Universität Zürich; Centro Nacional de Investigaciones Cardiovasculares; Dipartimenti di Eccellenza; Bristol-Myers Squibb; Science Foundation Ireland; Fundació la Marató de TV3; Worldwide Cancer Research; Fundación Científica Asociación Española Contra el Cáncer; Fundación Ramón Areces; Promedica Stiftung; Comunidad de Madrid; National Cancer Institute; Ministero dell’Istruzione, dell’Università e della Ricerca; Melanoma Research Alliance; Boehringer Ingelheim Fonds; Memorial Sloan-Kettering Cancer Center; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Cancer Research Institute","keywords":"Drug; Brain metastasis; Metastasis; Drug discovery; Medicine; Drug trafficking; Computational biology; Cancer research; Biology; Bioinformatics; Pharmacology; Internal medicine; Cancer; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001267497,0.0003589479,0.0008263107,0.0003107275,0.0003470579,0.00002629904,0.0001510398,0.00004347337,0.001330642],"category_scores_gemma":[0.0006001645,0.0002615405,0.0001797441,0.0004396942,0.000159611,0.00004261297,0.0001619498,0.0003793607,0.000009809541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001427753,"about_ca_system_score_gemma":0.00009183163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002703996,"about_ca_topic_score_gemma":0.00002701774,"domain_scores_codex":[0.9970633,0.0003387779,0.0006229891,0.0006289671,0.0009636343,0.0003823485],"domain_scores_gemma":[0.9981971,0.0005759469,0.0001424051,0.0006101354,0.00008608838,0.000388313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02197666,0.01723883,0.01981817,0.004454817,0.008142172,0.01263356,0.04590181,0.03401423,0.1775471,0.01408448,0.3738672,0.2703209],"study_design_scores_gemma":[0.1314427,0.1002903,0.09943728,0.006980349,0.01787002,0.002396756,0.07857755,0.0157495,0.1759121,0.01088988,0.3537727,0.006681013],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.944726,0.002106658,0.004419601,0.0446654,0.0002176292,0.00162158,0.00009930071,0.0001305337,0.002013235],"genre_scores_gemma":[0.9739087,0.00002063178,0.004841975,0.01851561,0.0001146219,0.0002811289,0.0003698219,0.00005722656,0.001890307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2636399,"threshold_uncertainty_score":0.9999837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02388341539319939,"score_gpt":0.3224262030911144,"score_spread":0.298542787697915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}