{"id":"W4213014073","doi":"10.1172/jci.insight.155636","title":"Trastuzumab/pertuzumab combination therapy stimulates antitumor responses through complement-dependent cytotoxicity and phagocytosis","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Centers for Disease Control and Prevention; National Institutes of Health; U.S. Department of Defense","keywords":"Pertuzumab; Trastuzumab; CD59; Cytotoxicity; In vivo; Complement system; Complement-dependent cytotoxicity; Cancer research; Phagocytosis; Medicine; Pharmacology; Combination therapy; Immunology; Antibody; Antibody-dependent cell-mediated cytotoxicity; Biology; In vitro; Monoclonal antibody; Cancer; Internal medicine; Breast cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001385661,0.0002577723,0.0002214383,0.0002525775,0.00007989281,0.000224325,0.0001065127,0.0001735628,0.001033593],"category_scores_gemma":[0.0001285333,0.00006757677,0.000166566,0.0001043676,0.0001196369,0.0001124994,0.0001853752,0.0003103802,0.0001520888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000251423,"about_ca_system_score_gemma":0.0002110245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003227468,"about_ca_topic_score_gemma":0.0008748198,"domain_scores_codex":[0.9998319,0.00004612181,0.000009923845,0.00001520576,0.00004733494,0.00004954391],"domain_scores_gemma":[0.9999532,0.00001199108,0.000009778296,0.00000554616,0.000005529218,0.00001408576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007088758,0.0002492148,0.0007109621,0.00005907453,0.00001646875,0.0001513278,0.00001738939,0.0002579531,0.9822307,0.0002493167,0.0002226146,0.01512602],"study_design_scores_gemma":[0.0002848202,0.005664964,0.01940157,0.00001324878,0.00006595026,0.001204402,0.00002503075,0.003211506,0.9647331,0.0002369598,0.005150382,0.000008159057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993378,0.00250551,0.00129418,0.0001030657,0.00002464718,0.00005119746,0.00005392538,0.00004843682,0.002541054],"genre_scores_gemma":[0.997821,0.000551116,0.0005777623,0.00004526395,0.00002194391,0.00002230354,0.00005025293,0.00000352766,0.000906913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001033593,"threshold_uncertainty_score":0.003457725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07728773401432841,"score_gpt":0.3482257313292997,"score_spread":0.2709379973149713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}