{"id":"W4213023955","doi":"10.1038/s42003-022-03078-5","title":"Macrophage Jak2 deficiency accelerates atherosclerosis through defects in cholesterol efflux","year":2022,"lang":"en","type":"article","venue":"Communications Biology","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; McGill University Health Centre; Royal Victoria Regional Health Centre; Royal Victoria Hospital; University Health Network; Toronto General Hospital; University of Toronto; Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Macrophage; Efflux; Janus kinase 2; Bone marrow; Cholesterol; Coronary atherosclerosis; Biology; Haematopoiesis; Endocrinology; Apolipoprotein E; Internal medicine; Foam cell; Immunology; Cancer research; Cell biology; Medicine; Signal transduction; Lipoprotein; In vitro; Biochemistry; Stem cell; Coronary artery disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001778241,0.0005382641,0.000318749,0.0004202822,0.0001709735,0.0003313232,0.0001762255,0.0004369121,0.002377027],"category_scores_gemma":[0.0001217145,0.0002033068,0.0002117698,0.000128541,0.0002703005,0.0001801735,0.0002298262,0.0007114506,0.0005944851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000151801,"about_ca_system_score_gemma":0.000164866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002203881,"about_ca_topic_score_gemma":0.0003795474,"domain_scores_codex":[0.9997963,0.00004589814,0.00002268291,0.00003031473,0.00005576572,0.00004902607],"domain_scores_gemma":[0.9997912,0.00003810946,0.00005797327,0.00001843549,0.00001415381,0.0000801048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002780817,0.0000856033,0.000282646,0.00002156347,0.000003829959,0.0001557092,0.000007166662,0.00003538441,0.9983114,0.0001017267,0.00005175245,0.0006651176],"study_design_scores_gemma":[0.00009168294,0.0007619632,0.006948706,0.00001405343,0.00002357972,0.001811648,0.00003165929,0.001059555,0.9870407,0.0001230122,0.002085632,0.000007854867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955063,0.0009760553,0.001561773,0.0001318568,0.00004219694,0.00002608835,0.0003825084,0.0001079139,0.001265348],"genre_scores_gemma":[0.9949411,0.0005366298,0.001134903,0.00006139131,0.00001876945,0.00002928099,0.000283808,0.00002688153,0.002967228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002377027,"threshold_uncertainty_score":0.007951975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04154760042869902,"score_gpt":0.2828855475846785,"score_spread":0.2413379471559795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}