{"id":"W4213025187","doi":"10.1200/jco.2022.40.6_suppl.279","title":"Safety and preliminary clinical activity of JNJ-63898081 (JNJ-081), a PSMA and CD3 bispecific antibody, for the treatment of metastatic castrate-resistant prostate cancer (mCRPC).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of British Columbia; BC Cancer Agency","funders":"Janssen Research and Development","keywords":"Medicine; Enzalutamide; Prostate cancer; Internal medicine; Pharmacokinetics; Pharmacodynamics; Cancer; Oncology; Pharmacology; Urology; Gastroenterology; Androgen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009933005,0.0005469816,0.000550678,0.0003011749,0.0002305856,0.0004403757,0.0005999391,0.0005876696,0.001325907],"category_scores_gemma":[0.0008000222,0.0002646201,0.0004772404,0.0002185615,0.00049874,0.0003455768,0.0001658016,0.001471049,0.0004583695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005640843,"about_ca_system_score_gemma":0.000881261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001107307,"about_ca_topic_score_gemma":0.002310552,"domain_scores_codex":[0.9996663,0.0001607745,0.00002228118,0.00003839763,0.00006321396,0.00004901259],"domain_scores_gemma":[0.999376,0.0001184554,0.0002134701,0.0000585822,0.00005233062,0.0001811514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2538936,0.1036978,0.03692392,0.001007303,0.0007690233,0.0006649436,0.0006858516,0.005486763,0.29835,0.0004481431,0.005731997,0.2923407],"study_design_scores_gemma":[0.04027434,0.8591369,0.06256791,0.00004897749,0.0003931589,0.000914375,0.00007364933,0.001952999,0.02866784,0.0001187454,0.005818069,0.00003304909],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963962,0.001119868,0.0003417622,0.0001055121,0.00002170325,0.0004292727,0.0003420605,0.00004373746,0.001199753],"genre_scores_gemma":[0.9959154,0.0008638343,0.000474077,0.0001694084,0.00004416006,0.0003072981,0.0008798657,0.00001371348,0.001332287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001325907,"threshold_uncertainty_score":0.005253136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2140146262564204,"score_gpt":0.5365450964972351,"score_spread":0.3225304702408148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}