{"id":"W4213029728","doi":"10.21203/rs.3.rs-128652/v1","title":"The Curcumin Analog (PAC) Has Anti-Oral Cancer Properties Through Impairing Pro-Survival Signaling Pathways and Activating the Cell Death Processes Apoptosis and Autophagy","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Curcumin's Biomedical Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Viability assay; Cancer cell; Chemistry; Apoptosis; Wnt signaling pathway; Programmed cell death; Cell biology; Cancer research; Signal transduction; Cell growth; Curcumin; Cancer; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006648268,0.0003146299,0.0002256208,0.0003167116,0.0001135642,0.0001008006,0.0001088768,0.0002194479,0.001458671],"category_scores_gemma":[0.00006669731,0.0001074807,0.0002187614,0.0001322976,0.0001134107,0.0001415993,0.0001070047,0.000303778,0.0003468533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001566364,"about_ca_system_score_gemma":0.0001765555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003474188,"about_ca_topic_score_gemma":0.0008051152,"domain_scores_codex":[0.9999523,0.000007938048,0.000005240578,0.00001168059,0.00001265561,0.00001020728],"domain_scores_gemma":[0.9999635,0.000006521394,0.000009783716,0.000004837414,0.000007534451,0.00000782621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002392707,0.00006486611,0.0001922599,0.0003832652,0.00001500609,0.0001287921,0.000008724165,0.00008045563,0.9921653,0.00005499259,0.0001743231,0.006492683],"study_design_scores_gemma":[0.00004997786,0.001117847,0.004465348,0.00002424082,0.00005110809,0.0008063076,0.00001987445,0.0002968208,0.9820034,0.00004897069,0.01110782,0.000008182435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9622404,0.0265495,0.004168259,0.0003899676,0.0001291973,0.0001634071,0.001091427,0.0002141677,0.005053673],"genre_scores_gemma":[0.9858964,0.007434636,0.002793479,0.0001177323,0.00002670938,0.00009014227,0.0007736071,0.00001442828,0.002852886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001458671,"threshold_uncertainty_score":0.004879773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1665773709069668,"score_gpt":0.3769114729321862,"score_spread":0.2103341020252194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}