{"id":"W4213031527","doi":"10.1007/s13555-022-00690-5","title":"Cumulative Clinical Benefits of Biologics in the Treatment of Patients with Moderate-to-Severe Psoriasis over 1 Year: a Network Meta-Analysis","year":2022,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"Manchester Biomedical Research Centre; National Institute for Health and Care Research; Dermira; Castle Biosciences; Galderma; Bristol-Myers Squibb; Eli Lilly and Company; Ortho Dermatologics; Sanofi Genzyme; Incyte; UCB Pharma; Sun Pharma; Regeneron Pharmaceuticals; Celgene; Sanofi; Amgen; Pfizer","keywords":"Psoriasis Area and Severity Index; Medicine; Psoriasis; Internal medicine; Placebo; Clinical trial; Randomized controlled trial; Ixekizumab; Gastroenterology; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002304107,0.0001848321,0.001039245,0.0001338762,0.0001513056,0.000002745618,0.0001465755,0.0001410191,0.0003556465],"category_scores_gemma":[0.000005656093,0.00009902348,0.0003605839,0.0004667903,0.0001375598,0.00002354254,0.00002856161,0.00009396896,0.00000283802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001026165,"about_ca_system_score_gemma":0.00002069153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006155449,"about_ca_topic_score_gemma":0.00006679064,"domain_scores_codex":[0.9978715,0.001186625,0.0004118193,0.000275932,0.00004763619,0.0002065306],"domain_scores_gemma":[0.9988591,0.0005862729,0.000222882,0.0002730373,0.00004458822,0.00001411069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004792867,0.001658416,0.9186834,0.000002171512,0.06253517,0.000005446958,0.00214722,0.002247139,0.000006168399,0.001185433,0.00009350872,0.006643124],"study_design_scores_gemma":[0.009838338,0.003219131,0.9595038,0.000001357509,0.02080526,0.00001548443,0.0003468828,0.00002207435,0.0004306296,0.0005596867,0.00500608,0.0002512574],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883936,0.0105626,0.00001430245,0.0001408643,0.00009385533,0.0004364831,0.0002954654,0.000007137773,0.000055664],"genre_scores_gemma":[0.9980763,0.001143112,0.00007946711,0.000259518,0.000006462313,0.0001566558,0.0002311521,0.000006992898,0.0000403703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04172992,"threshold_uncertainty_score":0.4038061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0738873349008602,"score_gpt":0.3023967785833831,"score_spread":0.2285094436825229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}