{"id":"W4213036963","doi":"10.3390/cells11040748","title":"The Role of MeCP2 in Regulating Synaptic Plasticity in the Context of Stress and Depression","year":2022,"lang":"en","type":"review","venue":"Cells","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Canadian Institutes of Health Research","keywords":"MECP2; Neuroscience; Synaptic plasticity; Neuroplasticity; Biology; Rett syndrome; Regulator; Context (archaeology); Epigenetics; Chronic stress; Psychology; Genetics; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003074135,0.0006393355,0.0007708689,0.001182992,0.0001708992,0.0005798913,0.000662772,0.0009104412,0.001395884],"category_scores_gemma":[0.0004187198,0.0001748377,0.0002960742,0.001084596,0.0003353057,0.0007407167,0.0004822343,0.001129314,0.0008876328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005513179,"about_ca_system_score_gemma":0.0006872818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001030305,"about_ca_topic_score_gemma":0.001852281,"domain_scores_codex":[0.9999183,0.00001563732,0.00001320516,0.00001443223,0.00002675954,0.00001161517],"domain_scores_gemma":[0.9998857,0.00005375941,0.00001545188,0.000003127693,0.00002862623,0.00001336535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001234264,0.00004182593,0.00024503,0.01340024,0.0001050745,0.000360938,0.00006230756,0.0004637292,0.004263941,0.003593822,0.02788481,0.9494548],"study_design_scores_gemma":[0.0000296451,0.0001209968,0.002161145,0.003523788,0.0001506512,0.00265532,0.00006379953,0.0001644446,0.001288432,0.002595455,0.9872226,0.00002365593],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001305897,0.9989999,0.00006956951,0.0001909067,0.0001184044,0.000001703323,0.000009886739,0.000004162943,0.0004748895],"genre_scores_gemma":[0.0008050348,0.9984294,0.0001036882,0.0001558223,0.0001098969,0.00000418409,0.00002053985,9.815766e-7,0.0003705831],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001395884,"threshold_uncertainty_score":0.004669666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01333200528794241,"score_gpt":0.2472033571003164,"score_spread":0.233871351812374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}