{"id":"W4213036963","doi":"10.3390/cells11040748","title":"The Role of MeCP2 in Regulating Synaptic Plasticity in the Context of Stress and Depression","year":2022,"lang":"en","type":"review","venue":"Cells","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Canadian Institutes of Health Research","keywords":"MECP2; Neuroscience; Synaptic plasticity; Neuroplasticity; Biology; Rett syndrome; Regulator; Context (archaeology); Epigenetics; Chronic stress; Psychology; Genetics; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001440765,0.0001144511,0.0002667873,0.00002881759,0.00003664371,0.00000582056,0.0002346024,0.00007751175,0.000004253567],"category_scores_gemma":[0.00005548238,0.00007002499,0.00005909262,0.00007747997,0.00006533788,5.468763e-7,0.0001976043,0.0001173233,1.498946e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005384751,"about_ca_system_score_gemma":0.00005036912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002405459,"about_ca_topic_score_gemma":0.0001072595,"domain_scores_codex":[0.9991588,0.0001641642,0.000299645,0.000178652,0.0000921859,0.0001065821],"domain_scores_gemma":[0.9995031,0.0001388811,0.0001753397,0.000162496,0.000008546956,0.00001165256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002403205,0.00009515043,0.0004864128,0.002242342,0.00005137493,0.000002118994,0.0003320187,0.00004396803,0.0164751,0.00003138221,0.00003558418,0.9801805],"study_design_scores_gemma":[0.0007344174,0.0002773411,0.001915284,0.003382697,0.0001631332,0.00001204199,0.005058783,0.0001286945,0.05211925,0.0001297478,0.9355707,0.0005079005],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.08015561,0.9192262,0.000001039649,0.000001878525,0.00004024097,0.0002839736,0.00002564195,4.666883e-7,0.0002649753],"genre_scores_gemma":[0.3109834,0.6889416,0.000007576758,0.000005647411,0.000002985229,0.00002181743,0.00002041041,0.000007933496,0.000008630414],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9796726,"threshold_uncertainty_score":0.2855536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01333200528794241,"score_gpt":0.2472033571003164,"score_spread":0.233871351812374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}