{"id":"W4213037982","doi":"10.1093/jcag/gwab049.242","title":"A243 HISTAMINE H1-RECEPTOR ANTAGONISTS SUPPRESS THE HYPEREXCITABILITY OF NOCICEPTIVE NEURONS EXPOSED TO IBS-C PATIENT STOOL SUPERNATANTS","year":2022,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Histamine; Dorsal root ganglion; Medicine; Nociception; Nociceptor; Irritable bowel syndrome; Receptor; Histamine H1 receptor; Pyrilamine; Histamine receptor; Constipation; Internal medicine; Pharmacology; Anesthesia; Antagonist; Dorsum","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001283923,0.000355681,0.0005103229,0.000195285,0.0002195182,0.0002049203,0.0002305166,0.0003567476,0.00461728],"category_scores_gemma":[0.000161609,0.0001688132,0.0004011419,0.0001406734,0.0001992042,0.0002020283,0.0001705521,0.0007103413,0.0006902813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000133698,"about_ca_system_score_gemma":0.0002429406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003904412,"about_ca_topic_score_gemma":0.0008816851,"domain_scores_codex":[0.9998809,0.00001725766,0.0000121232,0.00001627535,0.0000173724,0.00005592825],"domain_scores_gemma":[0.99991,0.00001440037,0.00001809186,0.000007872816,0.00001163172,0.00003797836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00277932,0.0005236987,0.0002934046,0.0001358088,0.00002295783,0.00009071734,0.0000217775,0.00003555494,0.9928817,0.00002276156,0.0002245798,0.002967807],"study_design_scores_gemma":[0.0009119518,0.03245979,0.05360948,0.00007524482,0.0001417226,0.001051207,0.0003530902,0.001609833,0.9063233,0.0001304915,0.003305205,0.00002875138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965118,0.001419353,0.0004234829,0.00009766057,0.00008828738,0.00005267508,0.0002819743,0.00004686721,0.001077957],"genre_scores_gemma":[0.9947175,0.001237507,0.0009651347,0.0001713678,0.00004607101,0.0001144318,0.0006623123,0.00001155469,0.002073938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00461728,"threshold_uncertainty_score":0.01544631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01075992404169298,"score_gpt":0.2174610493746791,"score_spread":0.2067011253329861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}