{"id":"W4213041732","doi":"10.1038/s41397-022-00266-8","title":"HLA-B*07:02 and HLA-C*07:02 are associated with trimethoprim-sulfamethoxazole respiratory failure","year":2022,"lang":"en","type":"article","venue":"The Pharmacogenomics Journal","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University and Génome Québec Innovation Centre","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Human Genome Research Institute; Foundation for the National Institutes of Health","keywords":"Human leukocyte antigen; Genotyping; HLA-B Antigens; Immunology; Haplotype; Medicine; Trimethoprim; Population; Cohort; Biology; Genetics; Allele; Internal medicine; Genotype; Gene; Antigen; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.002847685,0.0003693103,0.0005741958,0.0003293927,0.001522833,0.0001031576,0.0003927584,0.0000964349,0.0004476573],"category_scores_gemma":[0.0002572928,0.0002791079,0.0002336736,0.0005308026,0.0001901317,0.0002107855,0.0002692091,0.002946275,0.00005809406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001075301,"about_ca_system_score_gemma":0.0007038839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001790943,"about_ca_topic_score_gemma":0.000009597228,"domain_scores_codex":[0.9970118,0.0006610021,0.0005771569,0.000396615,0.0007199071,0.0006334754],"domain_scores_gemma":[0.9976257,0.000452872,0.0007443291,0.0004188303,0.0002465432,0.0005117414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001311783,0.001447959,0.007852243,0.00006859372,0.004511848,0.002353706,0.004206108,0.004498888,0.8842885,0.0001615973,0.01718731,0.07211146],"study_design_scores_gemma":[0.02145825,0.0005713801,0.02683166,0.000211947,0.004211631,0.0161734,0.0116417,0.001614354,0.03223855,0.0006166284,0.8831491,0.001281408],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985772,0.001620361,0.0002085177,0.006382619,0.0007003217,0.0006438738,0.0001369303,0.0001080659,0.004427365],"genre_scores_gemma":[0.9925205,0.0003246757,0.000604178,0.003905681,0.0008476294,0.00004402899,0.00001694681,0.0001323263,0.001604019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8659618,"threshold_uncertainty_score":0.9999661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04633719457366831,"score_gpt":0.3088909608665956,"score_spread":0.2625537662929273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}