{"id":"W4213044498","doi":"10.1080/10428194.2022.2042689","title":"Enhanced cytotoxicity of bisantrene when combined with venetoclax, panobinostat, decitabine and olaparib in acute myeloid leukemia cells","year":2022,"lang":"en","type":"article","venue":"Leukemia & lymphoma/Leukemia and lymphoma","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institutes of Health","keywords":"Decitabine; Panobinostat; Cancer research; PARP1; Olaparib; Azacitidine; Myeloid leukemia; Cytotoxicity; Pharmacology; PI3K/AKT/mTOR pathway; Poly ADP ribose polymerase; Chemistry; Leukemia; Vorinostat; Apoptosis; Histone deacetylase; Medicine; DNA methylation; In vitro; Immunology; Histone; Polymerase; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000130956,0.0003681296,0.0003672459,0.000289245,0.0001373747,0.00022732,0.0001522024,0.0001849661,0.001011188],"category_scores_gemma":[0.0001218191,0.00009378068,0.000225649,0.0002806885,0.0001270612,0.0001779737,0.0001633008,0.0003465419,0.0002238185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001620209,"about_ca_system_score_gemma":0.0002575689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008963917,"about_ca_topic_score_gemma":0.001455482,"domain_scores_codex":[0.9998713,0.00003811324,0.00001546292,0.00002315433,0.00002902214,0.00002302996],"domain_scores_gemma":[0.9999213,0.00001876776,0.00001497434,0.00001313028,0.00001013283,0.00002167011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006990317,0.0001141642,0.0003924099,0.00007675296,0.00001438755,0.00007435975,0.00002626393,0.0001647237,0.9928728,0.00006147016,0.00007901321,0.00542449],"study_design_scores_gemma":[0.00006597188,0.002040371,0.005522808,0.0000078803,0.00003764112,0.0003509315,0.0000166151,0.0005712708,0.9886135,0.00002420272,0.002744018,0.000004847584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933144,0.003342163,0.0006528429,0.00006628324,0.00004707547,0.00003519333,0.0003254456,0.00005303039,0.002163345],"genre_scores_gemma":[0.9948983,0.001392693,0.001231458,0.00002353994,0.00001869913,0.00003298256,0.0004896123,0.000007655254,0.001905074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001011188,"threshold_uncertainty_score":0.003382802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008695234625414798,"score_gpt":0.2345867560039069,"score_spread":0.2258915213784921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}